37345

O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

≥95.0% (HPLC)

• 동의어(들): N,N,N′,N′-Tetramethyl-O-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)uronium tetrafluoroborate, O-(4-Oxo-1,2,3-benzotriazin-3(4H)-yl)-N,N,N′,N′,-tetramethyluronium tetrafluoroborate, TDBTU
• 실험식(Hill 표기법): C₁₂H₁₆BF₄N₅O₂
• CAS Number: 125700-69-8
• Molecular Weight: 349.09
• MDL number: MFCD00077730
• UNSPSC 코드: 12352100
• PubChem Substance ID: 57649719

속성

• 분석: ≥95.0% (HPLC)
• 양식: solid
• solubility: acetonitrile: 0.1 g/mL, clear
• 저장 온도: 2-8°C
• SMILES string: F[B-](F)(F)F.CN(C)\C(ON1N=Nc2ccccc2C1=O)=[N+](\C)C
• InChI: 1S/C12H16N5O2.BF4/c1-15(2)12(16(3)4)19-17-11(18)9-7-5-6-8-10(9)13-14-17;2-1(3,4)5/h5-8H,1-4H3;/q+1;-1
• InChI key: FOBCPCIJLQTYBT-UHFFFAOYSA-N

설명

애플리케이션

O-(3,4-Dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (2-(3,4-dihydro-4-oxo-1,2,3-benzotriazin-3-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, TBTU) may be used as:

• coupling reagent in the synthesis of macrocyclic polyamine derivatives with various length of linkers[1]
• condensation reagent in the large-scale preparation of the hematoregulatory nonapeptide (Glp-Glu-Asp)₂-DAS-(Lys)₂ (2,SK&F 107647)[2]
• coupling reagent for peptide synthesis which best suppresses racemization during fragment condensation[3]

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H317,H319
• 예방조치 성명서: P261 - P264 - P272 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1A
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves