188778

5-Amino-2-chloropyridine

98%

• 실험식(Hill 표기법): C₅H₅ClN₂
• CAS Number: 5350-93-6
• Molecular Weight: 128.56
• Beilstein: 108891
• EC Number: 226-322-3
• MDL number: MFCD00006243
• UNSPSC 코드: 12352100
• PubChem Substance ID: 24851317
• NACRES: NA.22

속성

• Quality Level: 200
• 분석: 98%
• 양식: solid
• mp: 81-83 °C (lit.)
• 작용기: chloro
• SMILES string: Nc1ccc(Cl)nc1
• InChI: 1S/C5H5ClN2/c6-5-2-1-4(7)3-8-5/h1-3H,7H2
• InChI key: QAJYCQZQLVENRZ-UHFFFAOYSA-N

설명

일반 설명

5-Amino-2-chloropyridine undergoes Suzuki-Miyaura coupling with sterically hindered 2,6-dimethylphenylboronic acid[1]. It undergoes facile temperature dependent displacement of chloride by bromide via Sandmeyer reaction to yield 2,5-dibromopyridine[2].

애플리케이션

5-Amino-2-chloropyridine was used in the synthesis of [²H₅]2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine[3]. It was used in identification and evaluation of molecularly imprinted polymers for the selective removal of potentially genotoxic aminopyridine impurities from pharmaceuticals[4].

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves