142662

Chlorosulfonyl isocyanate

98%

• 동의어(들): N-Carbonylsulfamyl chloride, CSI
• Linear Formula: ClSO₂NCO
• CAS Number: 1189-71-5
• Molecular Weight: 141.53
• Beilstein: 1237247
• EC Number: 214-715-2
• MDL number: MFCD00011608
• UNSPSC 코드: 12352100
• PubChem Substance ID: 24848531
• NACRES: NA.22

속성

• vapor pressure: 5.57 psi ( 20 °C)
• Quality Level: 200
• 분석: 98%
• 형태: liquid
• refractive index: n20/D 1.447 (lit.)
• bp: 107 °C (lit.)
• mp: −44 °C (lit.)
• density: 1.626 g/mL at 25 °C (lit.)
• 저장 온도: 2-8°C
• SMILES string: ClS(=O)(=O)N=C=O
• InChI: 1S/CClNO3S/c2-7(5,6)3-1-4
• InChI key: WRJWRGBVPUUDLA-UHFFFAOYSA-N
• 유전자 정보: human ... ABCB1(5243) , FPR1(2357)

설명

일반 설명

Chlorosulfonyl isocyanate is classified as an isocyanate and is widely used as a reagent in sulfonylation and carbamoylation reactions.Chlorosulfonyl isocyanate reacts with hydrocarbon alkenes via stepwise dipolar pathway to give N-chlorosulfonyl-β-lactams.

애플리케이션

• Chlorosulfonyl isocyanate was used in synthesis and biochemical characterization of new class of membrane-associated glycosyltransferase inhibitors.
• It is synthetically versatile reagent and was used in the preparation of amides, lactams and triazocinones.
• It was employed in regio- and diastereoselective introduction of a protected amino group in synthesis of chiral, polyhydroxylated piperidines.
• It was used as reagent during the synthesis of novel sulfamides.

Employed in a regio- and diastereoselective introduction of a protected amino group in a synthesis of chiral, polyhydroxylated piperidines. Generation of ureas from amino groups in a synthesis of benzimidazolones.

안전성 정보

• 픽토그램: GHS08,GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H314,H317,H334
• 예방조치 성명서: P261 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
• 보충제 위험성: EUH014
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flash Point (°F): >230.0 °F
• Flash Point (°C): > 110 °C
• 개인 보호 장비: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter