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Merck
모든 사진(2)

문서

126020

Sigma-Aldrich

1,4-Dichlorophthalazine

95%

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About This Item

실험식(Hill 표기법):
C8H4Cl2N2
CAS Number:
Molecular Weight:
199.04
EC Number:
MDL number:
UNSPSC 코드:
12352100
PubChem Substance ID:
NACRES:
NA.22

분석

95%

mp

160-162 °C (lit.)

저장 온도

−20°C

SMILES string

Clc1nnc(Cl)c2ccccc12

InChI

1S/C8H4Cl2N2/c9-7-5-3-1-2-4-6(5)8(10)12-11-7/h1-4H

InChI key

ODCNAEMHGMYADO-UHFFFAOYSA-N

애플리케이션

1,4-Dichlorophthalazine was used as starting reagent in the synthesis of series of 4-aryl-1-(4-methylpiperazin-1-yl)phthalazines. It was used as coupling reagent in the synthesis of novel soluble polymer-bound ligand. It was often used as building block in medicinal chemistry synthesis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

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문서 라이브러리 방문

K De Wael et al.
Science & justice : journal of the Forensic Science Society, 55(6), 422-430 (2015-12-15)
Reactively-dyed black, navy blue and medium red cotton samples showing metamerism under fluorescent tube illumination were examined. Optical microscopy (bright field, polarization and fluorescence microscopy) was used, followed by microspectrometry in the visible range (MSP Vis), to differentiate the samples
Matthew A J Duncton et al.
Bioorganic & medicinal chemistry letters, 16(6), 1579-1581 (2006-01-03)
A novel class of 1-(isoquinolin-5-yl)-4-arylamino-phthalazines is described as inhibitors of vascular endothelial growth factor receptor II (VEGFR-2). Many compounds display VEGFR-2 inhibitory activity with an IC(50) as low as 0.017 microM in an HTRF enzymatic assay. The compounds also inhibit
A simple and effective soluble polymer-bound ligand for the asymmetric dihydroxylation of olefins: DHQD-PHAL-OPEG-OMe.
Kuang YQ, et al.
Tetrahedron Letters, 42(34), 5925-5927 (2001)
Synthesis of 4-aryl-1-(4-methylpiperazin-1-yl) phthalazines by Suzuki-type cross-coupling reaction.
Guery S, et al.
Synthesis, 2001(05), 699-701 (2001)
William H Bunnelle et al.
Journal of medicinal chemistry, 50(15), 3627-3644 (2007-06-26)
A series of exceptionally potent agonists at neuronal nicotinic acetylcholine receptors (nAChRs) has been investigated. Several N-(3-pyridinyl) derivatives of bridged bicyclic diamines exhibit double-digit-picomolar binding affinities for the alpha 4 beta 2 subtype, placing them with epibatidine among the most

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