콘텐츠로 건너뛰기
Merck

HTR2C

5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

동의어:
5-HT2C, 5-HTR2C, HTR1C
:
UniProtKB ID:
Clone ID:
  • Human(3358) Summary: Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
  • Mouse(15560) 5-hydroxytryptamine (serotonin) receptor 2C
  • Rat(25187) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • domestic cat(101099620) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • naked mole-rat(101726296) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • Horse(100057852) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • cow(538909) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • dog(450240) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
  • chicken(428707) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Agonist

제품 번호
설명
α-Methylserotonin maleate salt, ≥98% (HPLC),
human
Agomelatine, ≥98% (HPLC),
human
Nortriptyline hydrochloride, ≥98% (HPLC), powder,
human
Trazodone hydrochloride, ≥99% (HPLC), powder,
human
5-Carboxamidotryptamine maleate salt, powder, ≥98% (HPLC),
human, rat

Small Molecule - Allosteric Modulator

제품 번호
설명
DCEBIO, ≥98% (HPLC), solid,
human

Small Molecule - Antagonist

제품 번호
설명
4-Benzylpiperidine, 99%,
rat
Cyclobenzaprine hydrochloride, British Pharmacopoeia (BP) Reference Standard,
human
Cyclobenzaprine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
human
1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole, 98%,
rat
Cyclobenzaprine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
human

Antibodies

제품 번호
설명
종별 반응성
응용분야
Anti-5-HT-2C antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
immunofluorescence

immunohistochemistry
Anti-Serotonin Receptor 2C/HTR2C antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
종별 반응성
canine, human, mouse, rat
응용분야
ELISA
western blot
Anti-HTR2C antibody produced in rabbit, affinity isolated antibody,
종별 반응성
human, mouse, rat
응용분야
ELISA
western blot

Small Molecule - Blocker

제품 번호
설명
Trazodone hydrochloride, ≥99% (HPLC), powder,
human
Trimipramine maleate salt, ≥98% (TLC), powder,
human
Zimelidine dihydrochloride, solid,
human

Small Molecule - Inhibitor

제품 번호
설명
Trazodone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
human
Trazodone hydrochloride impurity standard, British Pharmacopoeia (BP) Reference Standard,
human
Trazodone hydrochloride, United States Pharmacopeia (USP) Reference Standard,
human
Trazodone hydrochloride, British Pharmacopoeia (BP) Reference Standard,
human
Nefazodone hydrochloride, United States Pharmacopeia (USP) Reference Standard,
human

Small Molecule - Ligand

제품 번호
설명
Nω-Methyl-5-hydroxy­trypt­amine oxalate salt, ≥90% (HPLC),
human

Small Molecule - Metabolite

제품 번호
설명
5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline,
human

Small Molecule - Mixed Agonist/Antagonist

제품 번호
설명
Mifepristone, ≥98%,
human, mouse, rat
Haloperidol, powder,
human, rat
Clozapine, ,
human, rat

Small Molecule - Precursor

제품 번호
설명
5-Hydroxy-L-tryptophan, powder,
human

esiRNA

제품 번호
설명
MISSION® esiRNA, targeting human HTR2C,
human