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1000420

USP

Abacavir Related Compound A

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

(1S,4R)-4-[2,6-Diamino-9H-purin-9-yl]-2-cyclopentene-1-methanol

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About This Item

Empirical Formula (Hill Notation):
C11H14N6O
CAS Number:
124752-25-6
Molecular Weight:
246.27
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

abacavir

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C11H14N6O/c12-9-8-10(16-11(13)15-9)17(5-14-8)7-2-1-6(3-7)4-18/h1-2,5-7,18H,3-4H2,(H4,12,13,15,16)/t6-,7+/m1/s1

InChI key

ZKJUXHDSLJYKED-RQJHMYQMSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Abacavir Related Compound A USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H318

Precautionary Statements

P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Y Wen et al.
Drug metabolism and disposition: the biological fate of chemicals, 27(1), 113-121 (1999-01-12)
Several in vitro and in situ approaches were used to determine the dominant presystemic activation site for (-)-6-aminocarbovir, (-)-carbocyclic 2',3'-didehydro-2', 3'-dideoxy-6-deoxy-6-aminoguanosine (6AC) conversion in rats. The in vitro disappearance half-lives (mean +/- S.D.) in the cytosolic fractions obtained from homogenates
C L Zimmerman et al.
Drug metabolism and disposition: the biological fate of chemicals, 20(1), 47-51 (1992-01-01)
The recently synthesized carbocyclic 2',3'-didehydro-2',3'-dideoxy-6-deoxy-6-amino-guanosine [(-)6AC] was evaluated as a prodrug for carbovir, carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine [(-)CBV] in seven male Sprague-Dawley rats. A randomized three-way cross-over design was used. Rats were assigned to receive the following treatments: a 20 mg/kg (-)6AC
Lack of effect of catheterization on the pharmacokinetics of (-)-carbovir in rats.
C L Zimmerman et al.
Pharmaceutical research, 13(9), 1417-1418 (1996-09-01)
Evaluation of gastrointestinal absorption and metabolism.
C L Zimmerman et al.
Drug metabolism reviews, 29(4), 957-975 (1998-01-09)
Y D Wen et al.
Pharmaceutical research, 12(6), 911-915 (1995-06-01)
Evaluate the ability of (-)-6-aminocarbovir ((-)-6AC) to improve the CNS exposure to (-)-carbovir ((-)-CBV). Activation of (-)-6AC in vitro was assessed by incubations of rat brain tissue homogenates. The in vivo brain exposure to (-)-CBV was then examined in rats
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Small Molecule HPLC

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