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SRP6182

Sigma-Aldrich

Human Serum Albumin

≥98% (SDS-PAGE)

Synonym(s):

GIG20, GIG42, HSA, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341, serum albumin

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

Assay

≥98% (SDS-PAGE)

form

liquid

mol wt

66.4 kDa

packaging

pkg of 1 mg

concentration

10 mg/mL

UniProt accession no.

P02768

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... ALBU(213)

General description

The gene HSA (human serum albumin) is mapped to human chromosome 4q13.3.[1] The gene encodes a protein of 585 amino acids with a molecular weight of 66.4kDa.[2] HSA is the most abundant protein in the plasma and has many metal-binding sites.[3][4]

Application

HSA (human serum albumin) has been used for the development of automated dye-binding method for serum albumin determination using bromcresol purple.[5] It has also been used to study effect of HSA on DNA transfection by lipoplexes.[6]

Biochem/physiol Actions

HSA (human serum albumin) mainly works as a carrier for various nutrients, metabolites and xenobiotics. It interacts with plasma zinc and regulates uptake of zinc in cells.[4] HSA plays a crucial role in drug pharmacokinetics.[3] It also controls oncotic pressure and volume of the blood.[7] Mutations in the gene are linked with congenital analbuminemia and familial dysalbuminemic hyperthyroxinemia.[1][8]

Physical form

Sterile filtered yellowish liquid.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
8K25L40160
8K24L40160
8F03L40160
8E09L40160
7H17L40160

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Structure and ligand binding properties of human serum albumin.
Kragh-Hansen U
Danish Medical Bulletin, 37, 57-84 (1990)
Structural basis of non-steroidal anti-inflammatory drug diclofenac binding to human serum albumin.
Zhang Y
Chemical Biology & Drug Design, 86, 1178-1184 (2015)
New automated dye-binding method for serum albumin determination with bromcresol purple.
Pinnell AE and Northam BE
Clinical Chemistry, 24, 80-86 (1978)
A nucleotide deletion and frame-shift cause analbuminemia in a Turkish family.
Caridi G
Biochemia Medica, 26, 264-271 (2016)
A nucleotide insertion and frameshift cause analbuminemia in an Italian family.
Watkins S
Proceedings of the National Academy of Sciences of the USA, 91, 2275-2279 (1994)
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Questions

1–3 of 3 Questions  

  1. What solvent can I use to dissolve albumin?

    1 answer

    1. This product is a prepared solution at 10 mg/mL. The 1 mg package will have a volume of 100 ul. The formulation of the diluent used to prepare this product is proprietary, however this product can be further diluted in PBS., medium, or other aqueous buffers. HSA, in powder form, can be dissolved in water or other buffers at up to 50 mg/mL.

      Helpful?

  2. Hi, this products CoA and SDS don't include the concentration. Is there a way we can get updated documentation to include the 10mg/mL?

    1 answer

    1. The final concentration of this product (SRP6182) is not tested or reported. This is a part of the production process. Should this information be required for your application see products A9080 or A6784. These are 30% and 10% solutions, respectively. The lot specific certificate of analysis for these products confirms the final concentration. The product can be further diluted based on this information to the desired concentration.

      Helpful?

  3. It says this is 1 mg and 200 mg/mL. That would mean the product is 5 microliters. Is this correct?

    1 answer

    1. This product is supplied at a concentration of 10mg/mL; therefore 1mg of material is contained in a volume of 100uL.

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