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SML1782

Sigma-Aldrich

CATPB

≥98% (HPLC)

Synonym(s):

(S)-3-(2-(3-Chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid

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5 MG
₩190,820

₩190,820

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5 MG
₩190,820

About This Item

Empirical Formula (Hill Notation):
C19H17ClF3NO3
CAS Number:
1322598-09-3
Molecular Weight:
399.79
UNSPSC Code:
12352200
PubChem Substance ID:
329826062
NACRES:
NA.77

₩190,820

In StockDetails

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(N[C@@H](CC1=CC=C(C(F)(F)F)C=C1)CC(O)=O)CC2=CC=CC(Cl)=C2

Biochem/physiol Actions

CATPB is an acetamidophenylbutanoate derivative with inverse agonist and antagonist activity against human, but not mouse or rat, FFA2 (GPR43). CATPB inhibits both constitutive and propionate (C3) -stimulated hFFA2 GTPγS incorporation (IC50 ~35 and 320 nM, respectively; [C3] = EC80, ~125 nM), as well as C3-induced hFFA2 G159E activity (IC50 ~400 nM). CATPB is shown to inhibit C3-induced intracellular ERK phosphorylation in hFFA2-expressing cells (IC50 ~3 μM against 10 mM C3).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000222889
106M4603V

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Liliana Íñiguez-Gutiérrez et al.
International journal of immunopathology and pharmacology, 34, 2058738420958949-2058738420958949 (2020-12-30)
Neutrophils represent the first line of host cellular defense against various pathogens. The most recently described microbicidal mechanism of these cells is the release of neutrophil extracellular traps (NET). Currently, a wide range of chemical and biological stimuli are known

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