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Key Documents

SML1775

Sigma-Aldrich

K-756

≥98% (HPLC)

Synonym(s):

3-[[1-(6,7-Dimethoxy-4-quinazolinyl)-4-piperidinyl]methyl]-3,4-dihydro-2(1H)-quinazolinone

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About This Item

Empirical Formula (Hill Notation):
C24H27N5O3
CAS Number:
Molecular Weight:
433.50
UNSPSC Code:
12352200

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

O=C1NC2=C(C=CC=C2)CN1CC3CCN(C4=C(C=C(OC)C(OC)=C5)C5=NC=N4)CC3

Biochem/physiol Actions

K-756 is an orally available, potent and selective tankyrase inhibitor, which binds to the induced-pocket of tankyrase. K-756 is a selective Wnt/β-catenin pathway inhibitor that stabilizes Axin and reduces active β-catenin. K-756 inhibits the proliferation of APC mutant colorectal cancer COLO 320DM and SW403 cell lines.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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