SML0214
SAMT-247
≥98% (HPLC)
Synonym(s):
3-(S-Acetylthiosalicyloyl)aminopropamide, N-[2-Acetylthiobenzoyl]-β-alaninamide
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About This Item
Empirical Formula (Hill Notation):
C12H14N2O3S
CAS Number:
Molecular Weight:
266.32
UNSPSC Code:
12352200
NACRES:
NA.77
Assay
≥98% (HPLC)
form
powder
color
white to light yellow
solubility
H2O: ≥2 mg/mL at 60 °C
storage temp.
2-8°C
Application
SAMT-247 may be used in HIV-1 related studies.
Biochem/physiol Actions
SAMT-247 inhibits HIV by modifying the nucleocapsid NCp7 region of Gag in infected cells, blocking Gag processing and reducing infectivity.
SAMT-247 is a microbicide that decreases the viral infectivity and infectivity of the progeny virus in HIV-1 infections.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Cecilia Cheng-Mayer et al.
AIDS (London, England), 25(15), 1833-1841 (2011-07-14)
Development of an effective vaccine or topical compound to prevent HIV transmission remains a major goal for control of the AIDS pandemic. Using a nonhuman primate model of heterosexual HIV-1 transmission, we tested whether a topical microbicide that reduces viral
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