SML0047
MoTP
≥98% (HPLC)
Synonym(s):
33N14, 4-(4-Morpholinobutylthio)phenol
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About This Item
Empirical Formula (Hill Notation):
C14H21NO2S
CAS Number:
Molecular Weight:
267.39
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥80 mg/mL
storage temp.
−20°C
SMILES string
Oc1ccc(SCCCCN2CCOCC2)cc1
InChI
1S/C14H21NO2S/c16-13-3-5-14(6-4-13)18-12-2-1-7-15-8-10-17-11-9-15/h3-6,16H,1-2,7-12H2
InChI key
YHKNLUTUXZDOQI-UHFFFAOYSA-N
Application
MoTP may be used in cell signaling and differentiation studies.
Biochem/physiol Actions
MoTP (also known as 33N14) reversibly blocks the specification of neural crest cells into melanocytes in zebrafish studies. Differentiation of neural crest cell-derived melanoblasts proceeds to late developmental stages, but they fail to reach the terminal stage of melanin production and die. Melanocytotoxicity is dependent on tyrosinase activity which convert it into a toxic form. MoTP specifically ablates only cells that express tyrosinase at high levels, which in the embryo are limited to melanoblasts and newly formed melanocytes. MoTP should be a useful tool for elucidating melanocyte stem cell regeneration, recruitment, and maintenance.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Kleio Petratou et al.
PloS one, 16(1), e0244794-e0244794 (2021-01-14)
Understanding how fate specification of distinct cell-types from multipotent progenitors occurs is a fundamental question in embryology. Neural crest stem cells (NCSCs) generate extraordinarily diverse derivatives, including multiple neural, skeletogenic and pigment cell fates. Key transcription factors and extracellular signals
Li Liu et al.
Biomolecules, 10(9) (2020-09-24)
It has been reported that 5-hydroxytryptamine (5-HT) is related to melanogenesis in mice and melanoma cells. However, the underlying mechanisms of 5-HT in regulating pigmentation remains unknown. In this study, we aim to clarify the regulatory mechanism of 5-HT in
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