European journal of pharmacology, 396(1), 33-37 (2000-05-24)
The increased endothelin-1 levels observed after smoking may result from nicotine-stimulated endothelin-1 production by endothelial cells. In this study, we investigated the effects of selective endothelin ET(A) receptors antagonist Cycle D-a-aspartyl-L-prolyl-D-isoleucyl-D-tryptophyl (JKC 301) and of endothelin ET(B) receptors antagonist N-cis-2
The Journal of pharmacology and experimental therapeutics, 275(1), 215-218 (1995-10-01)
In this study we characterized the endothelin (ET) receptors of cultured L6 myotubes in order to gain a further insight into the mechanism of the ET effect on skeletal muscle cells. Displacements of 125I-ET-1 by unlabeled ET-1, ET-2 and ET-3
Journal of mass spectrometry : JMS, 35(2), 265-276 (2000-02-19)
We previously showed by using mass spectrometry that endothelin A selective receptor antagonists BQ123 and JKC301 form novel coordination compounds with sodium ions. This property may underlie the ability of an ET(A) antagonist to induce net tubular sodium reabsorption in
American journal of physiology. Heart and circulatory physiology, 288(5), H2088-H2092 (2005-01-08)
Alpha-adrenergic vasoconstriction in the coronary circulation is mediated through alpha-adrenoceptors on cardiac myocytes and subsequent release of endothelin, a very potent, long-lasting vasoconstrictor. Recent studies found that adult cardiac myocytes do not express the preproendothelin gene. Thus we hypothesized that
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