Anti-Claudin 2 Antibody detects endogenous levels of total Claudin 2 protein.
Claudin-2 is one of the pore-forming claudins. It is a member of the claudin family of proteins. Claudin-2 is present in the proximal tubules. It is mapped to human chromosome Xq22.
Immunogen
The antiserum was produced against synthesized peptide derived from human Claudin 2.
Immunogen Range: 181-230
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Immunohistochemistry (1 paper)
Biochem/physiol Actions
The tetraspan membrane protein encoded by claudin multigene controls paracellular permeability and maintaining cell polarity in epithelial and endothelial cell sheets. In MDCK (madin-darby canine kidney cells) II cells, claudin-2 participates in the generation of aqueous pores with high conductance.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The choroid plexus epithelium (CPE) has served as a model-epithelium for cell polarization and transport studies and plays a crucial role for cerebrospinal fluid (CSF) production. The normal luminal membrane expression of Na(+),K(+)-ATPase, aquaporin-1 and Na(+)/H(+) exchanger 1 in the
The claudins
Lal-Nag M and Morin P J
Genome Biology (2009)
Conversion of Zonulae Occludentes from Tight to Leaky Strand Type by Introducing Claudin-2 into Madin-Darby Canine Kidney I Cells
Furuse M, et al.
The Journal of Cell Biology, 153(2), 263-272 (2001)
Inhibition of Autophagic Degradation Process Contributes to Claudin-2 Expression Increase and Epithelial Tight Junction Dysfunction in TNF-? Treated Cell Monolayers
Zhang C, et al.
International Journal of Molecular Sciences, 18(1) (2017)
Tumor necrosis factor-? induces a biphasic change in claudin-2 expression in tubular epithelial cells: role in barrier functions
Amoozadeh Y, et al.
American Journal of Physiology. Cell Physiology, 309(1), C38-C50 (2015)
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