Anti-Collagen XII α1 Antibody detects endogenous levels of total Collagen XII α1 protein.
Collagen XII α1 belongs to the FACIT collagens (fibril-associated collagens with interrupted triple helices) family. It codes for the alpha chain of type XII collagen. It is located on human chromosome 6q13.
Immunogen
The antiserum was produced against synthesized peptide derived from human Collagen XII alpha1.
Immunogen Range: 1481-1530
Application
Anti-Collagen XII α1 antibody has been used in immunohistochemistry.[1]
Biochem/physiol Actions
Collagen XII α1 participates in a benign bone tumor, subungual exostosis. Collagen XII organize the collagen fibrils and thereby preserves the bone and muscle integrity. Mutations in collagen XII results in Ehlers–Danlos/myopathy overlap syndrome.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Development of mammalian teeth and surrounding tissues includes time-space changes in the extracellular matrix composition and organization. This requires complex control mechanisms to regulate its synthesis and remodeling. Fibril-associated collagens with interrupted triple helices (FACITs) and a group of small
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 22(11), 1499-1506 (2009-08-04)
Chondromyxoid fibroma, a rare benign bone tumor, may be mistaken for chondrosarcoma. Although cytogenetic studies of chondromyxoid fibroma are few, rearrangements of the long arm of chromosome 6, frequently expressed as an inv(6)(p25q13), are prominent. In this study, conventional cytogenetic
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