Rift Valley Fever Virus Polymerase Antibody: Rift Valley Fever (RFV) virus is an arthropod-borne virus endemic to Africa that infects humans and animals that is transmitted predominantly by mosquitoes. During human infections, symptoms can range from benign fever to severe encephalitis and fatal hepatitis with hemorrhagic fever. The Bunyaviridae family of viruses to which the RVF virus belongs are spherical enveloped viruses with a tripartite RNA genome of negative or ambisense polarity. The three segments are referred to as the L, M, and S segments. The L and M segments are negative polarity and code fore the L-dependent RNA polymerase and glycoprotein precursor respectively. The S segment is of ambisense polarity and encodes the nucleoprotein and non-structural proteins.
Immunogen
RVF virus Polymerase antibody was raised against a 16 amino acid peptide near the amino terminus of the RVF virus Polymerase.The immunogen is located within amino acids 370 - 420 of Rift Valley Fever Virus Polymerase.
Application
RVF virus Polymerase antibody can detect 10 ng RVF virus Polymerase peptide in ELISA at 1 μg/mL.
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