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S3821

Sigma-Aldrich

Anti-phospho-Synaptotagmin (Ser309) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

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About This Item

MDL number:
MFCD08705500
UNSPSC Code:
12352203
NACRES:
NA.44

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

usage

sufficient for 10 blots

species reactivity

mouse, human, rat

technique(s)

dot blot: suitable
western blot: 1:1,000 using rat brain lysate

UniProt accession no.

P21579

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... SYT1(6857)
mouse ... Syt1(20979)
rat ... Syt1(25716)

General description

SYT1 (synaptotagmin-1) or phospho-Synaptotagmin is a calcium binding synaptic vesicle protein, that is located on chromosome 12q21. It is usually present in nerve cells.

Immunogen

synthetic phosphopeptide corresponding to amino acids residues surrounding the serine 309 of synaptotagmin (Syt).

Biochem/physiol Actions

Synaptotagmin-1 (SYT1) is an essential factor for exocytosis, endocytosis and vesicular Ca2+/H+ antiport activity.

Physical form

Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl with 100 μg/mL BSA and 50% glycerol.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Transancestral mapping and genetic load in systemic lupus erythematosus
Langefeld CD, et al.
Nature Communications, 8 (2017)
Differential Membrane Binding Mechanics of Synaptotagmin Isoforms Observed in Atomic Detail
Vermaas JV and Tajkhorshid E
Biochemistry, 56(1), 281-293 (2017)
Identification of a human synaptotagmin-1 mutation that perturbs synaptic vesicle cycling
Baker K, et al.
The Journal of Clinical Investigation, 125(4), 1670-1678 (2015)
Salvatore Santamaria et al.
mAbs, 9(4), 595-602 (2017-03-18)
The potent aggrecanase ADAMTS-5 is constitutively secreted by chondrocytes, but it is rapidly endocytosed in normal cartilage via the cell surface endocytic receptor LRP1. Therefore it is difficult to detect the total ADAMTS-5 activity produced. In this study, we isolated
Anna-Carina Weiss et al.
Development (Cambridge, England), 141(17), 3420-3430 (2014-08-21)
The vesico-ureteric junction (VUJ) forms through a complex developmental program that connects the primordium of the upper urinary tract [the nephric duct (ND)] with that of the lower urinary tract (the cloaca). The signals that orchestrate the various tissue interactions

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