R6148 is solution of 20 mg/ml RNAse A in Tris Buffer with 50% glycerol. A rough estimate of activity is 1000-2000 Kunitz units/ml.
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25 ML
₩410,872
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25 ML
₩410,872
About This Item
UNSPSC Code:
12352204
NACRES:
NA.52
Recommended Products
biological source
bovine pancreas
Quality Level
form
liquid
specific activity
1500 units/mL
3000 units/mL
concentration
20 mg/mL in Tris buffer
technique(s)
DNA purification: suitable
storage temp.
room temp
Gene Information
bovine ... RNASE1(282340) , RNASE1(280930)
General description
Ribonuclease A (RNase A), a protein composed of three α helices and seven β strands arranged in two "lobes” [1] holds significance as the prototypical domain-swapped protein.[2] It is known for its diverse oligomeric states.[2] The RNase A family derives its name from bovine pancreatic RNase A and is specific to vertebrates. In humans, this family encompasses eight functional members, showcasing its biological relevance.[3]
For sample preparation in GenElute™ kits.
For sample preparation in GenElute™ kits.
Application
Biochem/physiol Actions
Ribonuclease A or bovine pancreatic ribonuclease A (RNase A) enzyme is an endoribonuclease that displays a specific ability to cleave single-stranded RNA on the 3′ side of pyrimidine residues.[11] This endonuclease with 124 amino acids plays a key role in gene duplication, cellular metabolism, and cancer therapy. Its overexpression is closely associated with several types of cancer. Hence, RNase A has the potential to be a promising new biomarker for the diagnosis of malignant tumors and is also used as a specific target for new drug discovery.[12] RNase A is commonly used for the isolation of plasmid DNA.[13]
Preparation Note
For usage requirements, please refer to the kit procedure.
Legal Information
GenElute is a trademark of Sigma-Aldrich Co. LLC
sample prep
Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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