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PZ0178

Sigma-Aldrich

PHA 767491 hydrochloride

≥98% (HPLC)

Synonym(s):

1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride, 2-Pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one hydrochloride, PHA-00767491 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C12H11N3O · xHCl
CAS Number:
845538-12-7
Molecular Weight:
213.24 (free base basis)
MDL number:
MFCD11519962
UNSPSC Code:
51111800
PubChem Substance ID:
329823752
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

off-white to yellow

solubility

H2O: >25 mg/mL

SMILES string

Cl.O=C1NCCc2[nH]c(cc12)-c3ccncc3

InChI

1S/C12H11N3O.ClH/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12;/h1-2,4-5,7,15H,3,6H2,(H,14,16);1H

InChI key

IMVNFURYBZMFDZ-UHFFFAOYSA-N

Application

PHA 767491 hydrochloride has been used to study its effect on estrogen-induced DNA damage. It has also been used in western blot analysis and to study the S9.6 nuclear signal in HeLa cells.

Biochem/physiol Actions

PHA 767491 serves as a potential anticancer drug. It shows an ameliorating effect against acute myeloid leukemia, colon and breast cancer models. PHA 767491 possesses anti proliferating and apoptotic effect.
PHA-767491 is a potent and selective ATP-competitive dual inhibitor cdc7/cdk9. PHA-767491 blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage
Stork CT, et al.
eLife, 5, e17548-e17548 (2016)
The Initiation of DNA Replication in Eukaryotes, 289-289 (2016)
Medicinal Chemistry: Fusion of Traditional and Western Medicine, 382-382 (2014)
Transcription-replication conflict orientation modulates R-loop levels and activates distinct DNA damage responses
Hamper S, et al.
Cell, 170(4), 774-786 (2017)
Irene Gallina et al.
Molecular cell, 81(3), 442-458 (2020-12-16)
Lesions on DNA uncouple DNA synthesis from the replisome, generating stretches of unreplicated single-stranded DNA (ssDNA) behind the replication fork. These ssDNA gaps need to be filled in to complete DNA duplication. Gap-filling synthesis involves either translesion DNA synthesis (TLS)
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