PZ0177

OSU6162 hydrochloride

≥98% (HPLC)

• Synonym(s): PNU-96391; PNU-0096391; OSU-6162; (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine hydrochloride; (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride
• Empirical Formula (Hill Notation): C₁₅H₂₃NO₂S·HCl
• CAS Number: 156907-84-5
• Molecular Weight: 317.87
• MDL number: MFCD09753276
• UNSPSC Code: 51111800
• PubChem Substance ID: 329823751
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -5 to -7°, c = 1 in methanol
• color: white to tan
• solubility: H₂O: ≥16 mg/mL
• storage temp.: −20°C
• SMILES string: Cl.CCCN1CCC[C@H](C1)c2cccc(c2)S(C)(=O)=O
• InChI: 1S/C15H23NO2S.ClH/c1-3-9-16-10-5-7-14(12-16)13-6-4-8-15(11-13)19(2,17)18;/h4,6,8,11,14H,3,5,7,9-10,12H2,1-2H3;1H/t14-;/m1./s1
• InChI key: LEMGVHZVBREXAD-PFEQFJNWSA-N

Description

Biochem/physiol Actions

OSU6162 (PNU-96391) is a dopamine stabilizer, a drug that can stimulate or inhibit dopaminergic signaling depending on the dopaminergic tone. Dopaminergic stabilizers have been proposed to act as partial dopamine receptor agonists or as antagonists with both dopamine and behavioral stabilizing activity. Although affinity is not high (in vitro binding affinity for dopamine D2 receptor has a Ki of 447 nM), OSU6162 shows a high level of receptor occupancy.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H319
• Precautionary Statements: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable