I5404
IgG2, Kappa from human myeloma plasma
purified immunoglobulin, >95% (SDS-PAGE)
Synonym(s):
Human IgG2-κ
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1 MG
₩412,293
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1 MG
₩412,293
About This Item
application:
citations:
11
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biological source
human
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
Assay
>95% (SDS-PAGE)
shipped in
dry ice
storage temp.
−20°C
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General description
IgG antibody subtype is the most abundant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections.[1]
Human myeloma IgG2, κ is purified from human plasma by fractionation, ion-exchange and affinity chromatography procedures.
Human myeloma IgG2, κ is purified from human plasma by fractionation, ion-exchange and affinity chromatography procedures.
Application
The purified IgG2, κ may be used as an immunoglobulin calibrator, reference antigen, blocking agent or coating protein in a variety of immunoassays including ELISA, dot-blot immunobinding, Western immunoblotting, immunodiffusion, immunoelectrophoresis, hemagglutination, and cell-binding assays. Human myeloma IgG2, κa was used to characterize the trisulfide modifications in human and mouse antibodies[2] and in flow cytometry.[3]
Physical form
Solution in 0.02 M Tris buffered saline, pH 8.0.
Analysis Note
Identity is determined by immunoelectrophoresis and indirect ELISA.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Sheng Gu et al.
Analytical biochemistry, 400(1), 89-98 (2010-01-21)
Trisulfides are a posttranslational modification formed by the insertion of a sulfur atom into a disulfide bond. Although reports for trisulfides in proteins are limited, we find that they are a common modification in natural and recombinant antibodies of all
Jorn J Heeringa et al.
Allergy, 75(5), 1121-1132 (2019-10-07)
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Zhongqi Zhang et al.
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Human IgG antibodies containing terminal alpha 2,6-linked sialic acid on their Fc N-glycans have been shown to reduce antibody-dependent cell-mediated cytotoxicity and possess anti-inflammatory properties. Although terminal sialylation on complex N-glycans can happen via either an alpha 2,3-linkage or an
Misty W Stevens et al.
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Ch-mAb7F9, a human-mouse chimeric monoclonal antibody (mAb) designed to bind (+)-methamphetamine (METH) with high affinity and specificity, was produced as a treatment medication for METH abuse. In these studies, we present the preclinical characterization that provided predictive evidence that ch-mAb7F9
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