Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

H3021

Sigma-Aldrich

Antiflammin-2

≥97% (HPLC)

Synonym(s):

Anti-inflammatory peptide 2, His-Asp-Met-Asn-Lys-Val-Leu-Asp-Leu

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C46H77N13O15S
CAS Number:
118850-72-9
Molecular Weight:
1084.25
MDL number:
MFCD00153576
UNSPSC Code:
12352200
PubChem Substance ID:
24895545

Assay

≥97% (HPLC)

composition

Peptide content, ~65%

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(CC(O)=O)NC(=O)C(N)Cc1cnc[nH]1)C(=O)NC(CC(N)=O)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CC(C)C)C(O)=O

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Wayne B Anderson et al.
Chemical research in toxicology, 17(5), 650-662 (2004-05-18)
Dichloroacetic acid (DCA) is a drinking water contaminant, a therapeutic agent, and a rodent carcinogen. Glutathione transferase zeta (GSTZ1-1) catalyzes the biotransformation of a range of alpha-haloalkanoates and the cis-trans isomerization of maleylacetoacetate. GSTZ1-1 catalyzes the bioactivation of fluorine-lacking dihaloacetates
Q Li et al.
Ocular immunology and inflammation, 6(2), 65-73 (1998-08-05)
Phospholipase A2s (PLA2s) are a family of esterases that initiate the arachidonic acid cascade, which results in the production of numerous inflammatory mediators. We investigated the expression of Group I and II PLA2 proteins and Group II mRNA in normal
Degradation of antiflammin 2 in aqueous solution.
J L Wolfe et al.
Journal of pharmaceutical sciences, 83(12), 1762-1764 (1994-12-01)
J M Ye et al.
Journal of pharmaceutical sciences, 85(7), 695-699 (1996-07-01)
Antiflammin 2 (HDMNKVLDL, AF2) is a synthetic peptide derived from the region of highest sequence similarity of lipocortin I and uteroglobin, and is a potent antiinflammatory agent without any known side effects of corticosteroids. The antiinflammatory activity of AF2 has
S Lloret et al.
Biochemical pharmacology, 50(3), 347-353 (1995-07-31)
Antiflammins are synthetic peptides with sequence homology to proteins inhibitory for phospholipase A2 (EC 3.1.1.4). The effect of antiflammin 2 on murine arachidonate or 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear oedema has been studied. Topical application of arachidonic acid (AA) produced a
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service