This product is intended for research use only and not suitable for human or veterinary use. Currently, a food grade product is not available.
E7881
Emodin
from Frangula bark, ≥90% (HPLC), casein Kinase 2 (CK2) inhibitor
Synonym(s):
1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione, 1,3,8-Trihydroxy-6-methylanthraquinone, 6-Methyl-1,3,8-trihydroxyanthraquinone, Archin, Emodol, Frangula-emodin, Frangulic acid, Rheum emodin
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50 MG
₩253,953
250 MG
₩892,084
About This Item
Empirical Formula (Hill Notation):
C15H10O5
CAS Number:
Molecular Weight:
270.24
Beilstein:
1888141
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Product Name
Emodin, from Frangula bark, ≥90% (HPLC)
biological source
Frangula bark
Quality Level
Assay
≥90% (HPLC)
solubility
DMSO: soluble
aqueous base: soluble
ethanol: soluble
storage temp.
2-8°C
SMILES string
Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
InChI
1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
InChI key
RHMXXJGYXNZAPX-UHFFFAOYSA-N
Gene Information
human ... CSNK2A1(1457) , CSNK2B(1460) , ELA2(1991) , NFKB1(4790) , NKAP(79576) , NKRF(55922)
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General description
Emodin is an anthraquinone derivative, extracted from rhubarb (Rheum palmatum).[1] It has antibacterial,[1] anti-neoplastic, anti-inflammatory and anti-angiogenesis properties. Emodin exhibits cytotoxic effects, apoptosis and stimulates the expression of hypoxia-inducible factor 1α, glutathione S-transferase P and N-acetyltransferase.[2] It prevents the growth of prostate cancer cells.[1] Emodin is used to treat constipation and hemorrhoid. It displays immunosuppressive and anti-diabetic effects.[3]
Application
Emodin has been used:
- to investigate its regulatory mechanisms on lipopolysaccharide (LPS)-induced inflammatory injury in myocarditis[4]
- as a reference standard for the development and validation of high performance liquid chromatography (HPLC)-photodiode array (PDA) assay method[3]
- to inhibit Tau aggregation[5]
- for direct binding assay[6]
Biochem/physiol Actions
Inhibitor of NF-κB activation and adhesion molecule expression. Casein Kinase 2 (CK2) inhibitor.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Development and Validation of HPLC-PDA Assay method of Frangula emodin
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Mediterranean Journal of Chemistry, 5(2), 374-386 (2016)
Emodin and aloe-emodin suppress breast cancer cell proliferation through ERalpha inhibition
Huang PH, et al.
Evidence-Based Complementary and Alternative Medicine : ECAM, 2013 (2013)
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The Journal of Biological Chemistry, 290(27), 17029-17040 (2015)
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