Journal of steroid biochemistry, 20(4B), 1061-1065 (1984-04-01)
Although cystic lesions of the breast are not precancerous per se, statistical studies have indicated that this condition predisposes a 2- to 4-fold greater risk for breast cancer. Seeking a hormonal etiology to this correlation, investigators have analyzed breast cyst
Journal of steroid biochemistry, 24(1), 357-359 (1986-01-01)
The levels of progesterone receptors (PR [cytosol (Cy) and nuclear (N)] and estrogen receptors (ER) [cytosol and nuclear; occupied and unoccupied specific binding sites] were evaluated in the MCF-7 cancer cell line incubated with estriol (E3), estriol-3-sulfate (E3-3-S) or estriol-17-sulfate
The Journal of clinical endocrinology and metabolism, 53(4), 847-851 (1981-10-01)
The high concentration of estriol-3-sulfate (E3-3S) in human breast cyst fluid has been confirmed in 14 women with multiple cysts. The concentrations of E3-3S found in individual cysts drained within a short time span from the same patient were variable
Journal of steroid biochemistry, 20(4B), 1047-1055 (1984-04-01)
The biological responses of estriol (E3) and of estriol-3-sulfate (E3-S) in the fetal and newborn uteri of guinea pig were studied. After a treatment of E3 (1 mg/kg/day) or E3-S (1.4 mg/kg/day) to pregnant guinea pigs (49-60 days of gestation)
A novel synthesis of sodium 17-oxo-16 alpha-hydroxy-1,3,5(10)-estratrien-3-yl sulfate (4), sodium 16 alpha, 16 beta-dihydroxy-1,3,5(10)-estratrien-3-yl sulfate (5) and sodium 16-oxo-17 beta-hydroxy-1,3,5(10)-estratrien-3-yl sulfate (6) is described. 16 alpha-Bromo-3-hydroxy-1,3,5(10)-estratrien-17-one (1) was efficiently synthesized in one step with 70-97% yield by bromination of 3-hydroxy-1,3,5(10)-estratrien-17-one
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