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E4642
(±)-Epinephrine hydrochloride
≥98% (TLC), powder, adrenergic receptor agonist
Synonym(s):
(±)-Adrenalin, 4-(1-Hydroxy-2-[methylamino]ethyl)-1,2-benzenediol hydrochloride
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5 G
₩163,314
25 G
₩572,968
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5 G
₩163,314
25 G
₩572,968
About This Item
Empirical Formula (Hill Notation):
C9H13NO3 · HCl
CAS Number:
Molecular Weight:
219.67
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Product Name
(±)-Epinephrine hydrochloride,
Quality Level
solubility
H2O: 50 mg/mL
storage temp.
2-8°C
SMILES string
OC(CNC)C1=CC=C(O)C(O)=C1.Cl
InChI
1S/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H
InChI key
ATADHKWKHYVBTJ-UHFFFAOYSA-N
Gene Information
human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , ADRB1(153) , ADRB2(154) , ADRB3(155)
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General description
Epinephrine (adrenalin) is synthesized from norepinephrine (noradrenalin) by the action of the enzyme phenylethanolamine N-methyltransferase. Epinephrine comprises 5%-10% of the total catecholamines in the central nervous system.[1] It is a mixed α/β-adrenergic receptor agonist and stimulates these receptors.[2] Their site of synthesis is adrenal medulla and it travels through the vascular systems. Its breakdown occurs in the central nervous system (CNS), liver and kidney.[3]
Application
(±)-Epinephrine hydrochloride has been used:
- in the induction of renalase expression in Human renal proximal tubular epithelial cells[4]
- in the infusion studies to test its effect on heart rate and eye temperature measurements in bull[5]
- as a medium supplement for the stimulation of endothelial progenitor cells[6]
Biochem/physiol Actions
Epinephrine improves systemic pressure during cardiopulmonary resuscitation and is used post cardiac arrest. The levels of epinephrine increases during trauma, sepsis and hypoglycemia resulting in increased cardiac rate and contractility.[3] It is used in the treatment of acute anaphylaxis.[7] Use of epinephrine hydrochloride enables dilation of pupil during intraocular lens (IOL) implantation surgery.[8]
Adrenergic receptor agonist.
Other Notes
The ratio of +/- adrenaline is not determined.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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est ce que l'epinephrine de degrade a 37C et est ce qu'il est reversible?
1 answer-
Helpful?
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Can it be stored at -20C
1 answer-
The recommended storage temperature for this product is 2-8°C. In general, powder materials are not affected by freezer storage, however, this item has not been tested under these storage conditions.
Helpful?
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Hi, Do you have the ratio/ amount of D- and L-adrenaline in this product?
1 answer-
The ratio of +/- adrenaline is not determined.
Helpful?
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