D8907
1,2-Dioctanoylethylene glycol
~99%
Synonym(s):
Ethylene glycol dioctanoate
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About This Item
Empirical Formula (Hill Notation):
C18H34O4
CAS Number:
Molecular Weight:
314.46
MDL number:
UNSPSC Code:
41106300
PubChem Substance ID:
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Assay
~99%
form
liquid
storage temp.
−20°C
SMILES string
CCCCCCCC(=O)OCCOC(=O)CCCCCCC
InChI
1S/C18H34O4/c1-3-5-7-9-11-13-17(19)21-15-16-22-18(20)14-12-10-8-6-4-2/h3-16H2,1-2H3
InChI key
HTNFLUQQANUSLR-UHFFFAOYSA-N
Biochem/physiol Actions
Potent inhibitor of sn-1,2-diacylglycerol phosphorylation in vitro.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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P Nasmith et al.
Biochemical and biophysical research communications, 161(1), 95-100 (1989-05-30)
The diacylglycerol kinase inhibitors, R59022 and dioctanoylethylene glycol (diC8-eg), potentiate stimulation of the respiratory burst by the chemotactic tripeptide N-formyl-methionyl-leucyl-phenylalanine (fMLP) in human neutrophils. However, in contrast to the potentiation observed in intact cells, neither R59022 nor diC8-eg enhanced the
M Tóth et al.
Acta physiologica Hungarica, 81(4), 341-354 (1993-01-01)
Diacylglycerols (DAG) are assumed to play intracellular signal roles in rapidly growing tissues like those present in the primordial human placenta. The aim of the present study was to gain information on the capacity of DAG-kinase and CDP-choline: DAG phosphocholine
W R Bishop et al.
The Journal of biological chemistry, 261(15), 6993-7000 (1986-05-25)
Diacylglycerol kinase is though to play a central role in the metabolism of diacylglycerol second messengers in agonist-stimulated cells. A series of diacylglycerol analogs were tested for their ability to act as substrates or inhibitors of diacylglycerol kinase with the
S E Severin et al.
FEBS letters, 232(2), 286-288 (1988-05-23)
Diol lipids (dioleoyl- and dioctanoylethylene glycol) at relatively low concentrations (approximately 10 microM) were found to activate significantly protein kinase C in the presence of phosphatidylserine or phosphatidylinositol. Since diol lipids are widespread minor lipid constituents of many cells [(1974)
M Tóth
Biochimica et biophysica acta, 1210(1), 105-112 (1993-12-02)
Metabolic conversion of the synthetic DAG, dioctanoylglycerol (DOCG) into the dioctanoyl species of phosphatidic acid (PADOCG) and phosphatidylcholine (PCDOCG) in minced human primordial placenta incubated with [32P]phosphate was studied. Time-course experiments performed with 0.25 mM DOCG revealed a much higher
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