C3242

CDKi hydrochloride

≥98% (HPLC), solid

• Synonym(s): 2,4-Diamino-5-oxo-pyrimidine hydrochloride
• Empirical Formula (Hill Notation): C₄H₆N₄O · xHCl
• CAS Number: 70035-83-5
• Molecular Weight: 126.12 (free base basis)
• MDL number: MFCD08277042
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724437

Properties

• Assay: ≥98% (HPLC)
• form: solid
• solubility: H₂O: 21 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl[H].Nc1ncc(O)c(N)n1
• InChI: 1S/C4H6N4O.ClH/c5-3-2(9)1-7-4(6)8-3;/h1,9H,(H4,5,6,7,8);1H
• InChI key: KEFSYBXFZWLDQU-UHFFFAOYSA-N

Description

Biochem/physiol Actions

CDKi hydrochloride is a potent and selective ATP competitiive inhibitor of cycB-CDK1, cycE-CDK2, and cycD1-CDK4. Demonstrates significant inhibitory activity against a variety of tumor type both in vitro and in vivo.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves