A8754
Methyl α-aminoisobutyrate hydrochloride
Synonym(s):
α-Aminoisobutyric acid methyl ester hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C5H11NO2 · HCl
CAS Number:
Molecular Weight:
153.61
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
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Assay
≥98% (TLC)
form
powder
technique(s)
ligand binding assay: suitable
color
white
storage temp.
−20°C
SMILES string
Cl.COC(=O)C(C)(C)N
InChI
1S/C5H11NO2.ClH/c1-5(2,6)4(7)8-3;/h6H2,1-3H3;1H
InChI key
NVWZNEDLYYLQJC-UHFFFAOYSA-N
Biochem/physiol Actions
Methyl α-aminoisobutyrate is used as a specific substrate of amino acid transport system A in studies on amino acid transport systems.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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J W Tsang et al.
Journal of medicinal chemistry, 27(12), 1663-1668 (1984-12-01)
Stereochemical and structural aspects of the variations in the C-terminal residue of L-aspartyl-L-phenylalanine methyl ester have been investigated. Novel configurational analogues such as L-aspartyl-D-alanine benzyl ester and L-aspartyl-D-alpha-aminobutyric acid benzyl ester were found to be sweet. In addition, chiral and
Oak Z Chi et al.
Neurochemical research, 34(7), 1249-1254 (2009-01-08)
This study was performed to determine whether exogenous N-methyl-D: -aspartate (NMDA) or alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) would aggravate blood-brain barrier (BBB) disruption in focal cerebral ischemia in rats. Forty-five minutes after middle cerebral artery (MCA) occlusion, one of the following
A Gadea et al.
Glia, 26(4), 273-279 (1999-06-26)
Rapid termination of the synaptic action of glutamate (Glu) and glycine (Gly) is achieved by uptake into the presynaptic terminal and glial cells. In the vertebrate CNS, Gly acts both as an inhibitory neurotransmitter and as a Glu modulator or
Koichi Kato et al.
Bioorganic & medicinal chemistry letters, 21(8), 2437-2440 (2011-03-12)
We describe the synthesis of (11)C-labeled α-aminoisobutyric acid 2 from iodo[(11)C]methane and methyl N-(diphenylmethylen)-d,l-alaniate (5). The tetrabutylammonium fluoride (TBAF)-promoted α-[(11)C]methylation of sterically hindered analog 5 was a key step in our synthesis process. Total radiochemical conversion of 2 was high
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