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Supelco

2-(2-Methyl-5-nitro-1H-imidazol-1-yl)acetic acid

analytical standard

Synonym(s):

1-Carboxymethylmetronidazole, 2-Methyl-5-nitroimidazole-1-acetic acid, Metronidazole-1-acetic acid

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About This Item

Empirical Formula (Hill Notation):
C6H7N3O4
CAS Number:
1010-93-1
Molecular Weight:
185.14
Beilstein:
613770
MDL number:
MFCD01721819
UNSPSC Code:
41116107
PubChem Substance ID:
329764410
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥97.5% (GC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤0.5% water

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

O=C(O)CN1C(C)=NC=C1[N+]([O-])=O

InChI

1S/C6H7N3O4/c1-4-7-2-5(9(12)13)8(4)3-6(10)11/h2H,3H2,1H3,(H,10,11)

InChI key

RVEGZXNRNWUYKI-UHFFFAOYSA-N

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG1281
BCCF1730
BCBX5230
BCBQ9694V
BCBL3638V

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R A Gibson et al.
Clinical chemistry, 30(5), 784-787 (1984-05-01)
Metronidazole and its known metabolites in plasma can be rapidly separated by a "high-pressure" liquid-chromatographic method that can also be adapted for rapid determination of tinidazole. Samples deproteinized with trichloroacetic acid (50 g/L final concentration) undergo isocratic separation on a
B Salvesen et al.
Scandinavian journal of gastroenterology. Supplement, 91, 31-43 (1984-01-01)
A high-performance liquid chromatography (HPLC) method for the assay of metronidazole and its 2-hydroxymethyl metabolite in sera was compared with a microbiological method, an agar well diffusion technique with Clostridium perfringens as indicator strain. The HPLC technique involves separation of
O Eradiri et al.
Biopharmaceutics & drug disposition, 8(3), 249-259 (1987-05-01)
The pharmacokinetics of metronidazole (MTZ) were studied in six Crohn's disease patients after multiple oral daily doses of 250, 500, 750, and 1000 mg day-1. Pharmacokinetic indices were found to be independent of the dose administered. The half-life, volume of
D R Guay et al.
Antimicrobial agents and chemotherapy, 25(3), 306-310 (1984-03-01)
The pharmacokinetics of metronidazole, its biologically active alcohol metabolite, and its inactive acid metabolite were studied in five noninfected patients undergoing continuous ambulatory peritoneal dialysis and five patients undergoing hemodialysis. The latter were studied on off-dialysis days as a control
E D Ralph et al.
Sexually transmitted diseases, 7(4), 157-160 (1980-10-01)
The susceptibilities of strains of Gardnerella vaginalis (Haemophilus vaginalis), Neisseria gonorrhoeae, and Bacteroides fragilis to metronidazole and its principal oxidative metabolites (1-[2-hydroxyethyl]-2-hydroxymethyl-5-nitroimidazole) ("hydroxy" metabolite) and 1-acetic acid-2-methyl-5-nitroimidazole ("acid" metabolite), were compared by determinations of the minimal inhibitory concentrations (MICs) of
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