MPC4NTR10
Multiscreen® 96 well Plate, polycarbonate membrane
pore size 0.4 μm, non-sterile
Synonym(s):
96-Well Plate
About This Item
Recommended Products
material
flat bottom wells
polycarbonate membrane
polystyrene
Quality Level
description
This 96-well filter plate has a Polycarbonate membrane used for Permeability studies.
sterility
non-sterile
product line
MultiScreen®
feature
lid
manufacturer/tradename
MultiScreen®
parameter
100 μL sample volume (per well)
technique(s)
DNA purification: suitable
activity assay: suitable (with precipitations)
ligand binding assay: suitable
parallel artificial membrane permeation assay (PAMPA): suitable
receptor binding assay: suitable
plate size
96 wells
well maximum volume
300 μL
working volume
125 μL
pore size
0.4 μm pore size
application(s)
sample preparation
shipped in
ambient
General description
MultiScreen Permeability, MultiScreen-IP, and MultiScreen Acceptor plates support artificial membrane strategies for predicting passive transport.
Membranes have uniform pore structure and density for reliable transport:
- Individual wells minimize candidate cross-talk
- Compatibility with automated liquid handling systems increases throughput
Permeability Assay:
- The MultiScreen Permeability plate has a polycarbonate membrane, which supports a hexane/hexadecane artificial layer for permeability assays.1
PAMPA Assay:
- The MultiScreen-IP plate has a hydrophobic PVDF membrane, which supports a lipid bilayer for PAMPA asays.2,3
MultiScreen Acceptor Plate:
- The MultiScreen Acceptor plate can be used with either plate to capture passively transported compounds. Constructed of 100% PTFE, the plate can improve LC/MS results depending on the charge of the small molecules being evaluated.
Application
Assays
Protein
Physical form
Other Notes
Legal Information
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Articles
This is a white paper on the Evaluation of the reproducibility of Parallel Artificial Membrane Permeation Assays (PAMPA) using MultiScreen® Filter Plates.
This is a protocol for a Membrane Integrity test for Lipid-PAMPA Artificial Membranes
Combining solubility & PAMPA assays streamlines drug permeability testing.
Protocols
Assays that predict passive absorption of orally administered drugs have become increasingly important in the drug discovery process. As previously described by Faller and Kansy such assays provide rapid, low cost and automation friendly methods to measure a compound’s passive permeability.
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