Skip to Content
Merck
All Photos(2)

Documents

AB5864

Sigma-Aldrich

Anti-Myelin Basic Protein Antibody

serum, Chemicon®

Synonym(s):

MBP

Sign Into View Organizational & Contract Pricing


About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, rat

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... MBP(4155)
rat ... Mbp(24547)

Specificity

Recognizes Myelin Basic Protein in demyelinated nerve tissues. Immunohistochemistry analysis of lesioned rat spinal cord shows a high level of specificity for this antiserum.

Immunogen

Synthetic peptide corresponding to amino acids 69-86 of the guinea pig protein. Immunogen corresponds to "degraded" Myelin Basic Protein: YGSLPQKSQRSQDENPVV

Application

Anti-Myelin Basic Protein Antibody is an antibody against Myelin Basic Protein for use in IH.
Immunohistochemistry: 1:2,000. Immunostains myelin basic protein of abnormal appearing oligodendrocytic processes and cell bodies in demyelinating areas. The antibody recognizes only areas of myelin degeneration when tested in injured spinal cord and lesioned sciatic nerve. It also stains discrete white matter in brain of multiple system atrophy

Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Research Sub Category
Neuronal & Glial Markers

Neurodegenerative Diseases

Physical form

Rabbit Serum. Lyophilized, no preservatives. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any residue.
Unpurified

Storage and Stability

Maintain at -20 to -70°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.

Analysis Note

Control
Brain tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Role of myelin auto-antigens in pain: a female connection.
Veronica I Shubayev et al.
Neural regeneration research, 11(6), 890-891 (2016-08-03)
Brian D Clark et al.
Journal of neurotrauma, 20(7), 681-695 (2003-08-12)
Anatomical and physiological changes were evaluated in the median nerves of rats trained to perform repetitive reaching. Motor degradation was evident after 4 weeks. ED1-immunoreactive macrophages were seen in the transcarpal region of the median nerve of both forelimbs by
Yun Ju C Song et al.
The American journal of pathology, 171(4), 1291-1303 (2007-09-08)
p25alpha is an oligodendroglial protein that can induce aggregation of alpha-synuclein and accumulates in oligodendroglial cell bodies containing fibrillized alpha-synuclein in the neurodegenerative disease multiple system atrophy (MSA). We demonstrate biochemically that p25alpha is a constituent of myelin and a
Keying Zhu et al.
Frontiers in neuroscience, 10, 613-613 (2017-01-26)
Promoting remyelination is crucial for patients with demyelinating diseases including multiple sclerosis. However, it is still a circuitous conundrum finding a practical remyelinating therapy. Electroacupuncture (EA), originating from traditional Chinese medicine (TCM), has been widely used to treat CNS diseases
James Rice et al.
Acta neuropathologica communications, 7(1), 173-173 (2019-11-11)
Adolescent binge drinking represents a major public health challenge and can lead to persistent neurological and mental conditions, but the underlying pathogenic mechanisms remain poorly understood. Using a mouse model of adolescent binge ethanol treatment (ABET), we found that this

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service