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219457

Sigma-Aldrich

Cdk Inhibitor, p35 - CAS 471270-60-7 - Calbiochem

Synonym(s):

Cdk Inhibitor, p35 - CAS 471270-60-7 - Calbiochem, 2-(3-Hydroxypropylamino)-6-( o-hydroxybenzylamino)-9-isopropylpurine

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About This Item

Empirical Formula (Hill Notation):
C18H24N6O2
CAS Number:
Molecular Weight:
356.42
UNSPSC Code:
12352200

Pricing and availability is not currently available.

Assay

≥95% (HPLC)

Quality Level

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

This product has been discontinued.



An analog of Olomoucine (Cat. No. 495620) that acts as a potent inhibitor of Cdk1 (IC50 = 100 nM) and Cdk2 (IC50 = 80 nM). Also displays anti-proliferative and pro-apoptotic effects. The correlation between inhibition of Cdk1/Cdk2 and inhibition of cell proliferation suggests that the anti-proliferative effects are due, in part, to Cdk inhibition.

An analog of Olomoucine (Cat. No. 495620) that acts as a potent inhibitor of Cdk1 (IC50 = 100 nM) and Cdk2 (IC50 = 80 nM). Also displays anti-proliferative and pro-apoptotic effects.

Biochem/physiol Actions

Cell permeable: no
Primary Target
CDK1, CDK2
Product does not compete with ATP.
Reversible: no
Target IC50: 100 nM, 80 nM, against Cdk1 and Cdk2, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Vermeulen, K., et al. 2002. Leukemia16, 299.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10-13 - German Storage Class 10 to 13


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