07-189
Anti-Notch 4 Antibody
Upstate®, from rabbit
Synonym(s):
Anti-INT3
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... NOTCH4(4855)
Specificity
truncated, intracellular domain of Int3/Notch 4, possibly full-length Notch 4; does not cross-react with Notch 1, 2 or 3
Immunogen
His-tag fusion protein containing the carboxy-terminus of murine Notch 4
Application
Anti-Notch 4 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of Notch 4 & has been validated in WB.
Quality
routinely evaluated by immunoblot on lysates from 293 cells transfected with the intracellular domain of murine Notch 4
Target description
68kDa
Physical form
Format: Purified
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Ahmed Raafat et al.
Scientific reports, 7(1), 13690-13690 (2017-10-24)
Transgenic mice expressing the Notch-4 intracellular domain (designated Int3) in the mammary gland have two phenotypes exhibited with 100% penetrance: arrest of mammary alveolar/lobular development and mammary tumorigenesis. Notch-4 signaling is mediated primarily through the interaction of Int3 with the
Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats.
Sharon Bargo,Ahmed Raafat,David McCurdy,Idean Amirjazil,Youmin Shu,June Traicoff et al.
Biochemical and biophysical research communications null
Ahmed Raafat et al.
Journal of cellular physiology, 226(7), 1940-1952 (2011-04-21)
Notch genes play a critical role in mammary gland growth, development and tumorigenesis. In the present study, we have quantitatively determined the levels and mRNA expression patterns of the Notch receptor genes, their ligands and target genes in the postnatal
Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer.
Magnani, L; Stoeck, A; Zhang, X; Lanczky, A; Mirabella, AC; Wang, TL; Gyorffy, B; Lupien, M
Proceedings of the National Academy of Sciences of the USA null
S Zhang et al.
Oncogene, 35(19), 2485-2495 (2015-08-19)
Notch controls pancreatic differentiation during development and is reactivated in pancreatic cancer. In recent years, the importance of Notch signaling in pancreatic tumorigenesis has become increasingly evident; however, it remains unclear how Notch activities are regulated in this context. Here
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