05-857
Anti-phospho-Src family (Tyr416) Antibody, clone 2N8, rabbit monoclonal
clone 2N8, Upstate®, from rabbit
Synonym(s):
KAT13A
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
2N8, monoclonal
species reactivity
vertebrates, mouse
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
phosphorylation (pTyr416)
Gene Information
human ... SRC(6714)
Specificity
phospho-c-Src (Tyr416)
Immunogen
synthetic peptide containing the sequence ...NE[pY]TA, where pY corresponds to phosphotyrosine at position 416 of c-Src.
Application
Research Category
Signaling
Signaling
Research Sub Category
Cytoskeletal Signaling
Cytoskeletal Signaling
This Anti-phospho-Src family (Tyr416) Antibody, clone 2N8 is validated for use in WB for the detection of phospho-Src family (Tyr416).
Quality
Routinely evaluated by immunoblot of endogenous phospho-c-Src immunoprecipitated from NIH/3T3 RIPA lysates with anti-Src, clone GD11 agarose beads (Cat # 16-186)
Target description
60kDa
Linkage
Replaces: 16-249
Physical form
Format: Purified
Protein A purified
Storage and Stability
2 years at -20°C from date of shipment
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Structure and regulation of Src family kinases.
Boggon, Titus J and Eck, Michael J
Oncogene, 23, 7918-7927 (2004)
The interplay between Src family kinases and receptor tyrosine kinases.
Bromann, Paul A, et al.
Oncogene, 23, 7957-7968 (2004)
Molecular interdiction of Src-family kinase signaling in hematopoietic cells.
Geahlen, Robert L, et al.
Oncogene, 23, 8024-8032 (2004)
Suowen Xu et al.
Cellular signalling, 28(3), 117-124 (2015-12-27)
Endothelial dysfunction, characterized by impaired activation of endothelial nitric oxide (NO) synthase (eNOS) and ensued decrease of NO production, is a common mechanism of various cardiovascular pathologies, including hypertension and atherosclerosis. Laminar blood flow-mediated specific signaling cascades modulate vascular endothelial
Src protein-tyrosine kinase structure and regulation.
Roskoski, Robert
Biochemical and biophysical research communications, 324, 1155-1164 (2004)
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