R-011
Ritalinic acid hydrochloride solution
1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Empirical Formula (Hill Notation):
C13H17NO2 · HCl
CAS Number:
Molecular Weight:
255.74
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Recommended Products
grade
certified reference material
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
1.0 mg/mL in methanol (as free base)
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
forensics and toxicology
format
single component solution
storage temp.
−20°C
SMILES string
Cl.OC(=O)C(C1CCCCN1)c2ccccc2
InChI
1S/C13H17NO2.ClH/c15-13(16)12(10-6-2-1-3-7-10)11-8-4-5-9-14-11;/h1-3,6-7,11-12,14H,4-5,8-9H2,(H,15,16);1H
InChI key
SCUMDQFFZZGUQY-UHFFFAOYSA-N
General description
Ritalin®ic acid is a primary blood metabolite of methylphenidate, a psychostimulant sold under trade names Concerta® and Ritalin®. This Certified Snap-N-Spike® Solution is applicable for use in LC/MS or GC/MS applications for urine drug testing, clinical toxicology, and forensic analysis. Methylphenidate is prescribed for treatment of attention-deficit hyperactivity disorder (ADHD), tachycardia, and narcolepsy.
Application
- Genotoxicity research in non-human primates: Ritalinic acid hydrochloride, a primary metabolite of methylphenidate, is used in genetic toxicology studies to evaluate potential genotoxic effects, aiding in the assessment of safety profiles for neuropharmacological treatments (Morris et al., 2009).
- Pharmacokinetics and mutagenicity studies: Ritalinic acid hydrochloride is used in dose-range and mutagenicity research. It helps in studying the pharmacokinetics and toxicological impact of methylphenidate, offering important insights into its safety and effectiveness in therapeutic applications (Manjanatha et al., 2008).
- Bioequivalence and food effect studies: In clinical pharmacology, ritalinic acid hydrochloride is instrumental in conducting bioequivalence studies of dexmethylphenidate, examining the influence of food on drug absorption and metabolism, crucial for optimizing drug administration protocols (Teo et al., 2004).
- Childhood pharmacotherapy: Research using ritalinic acid hydrochloride explores the effects of methylphenidate when administered with or without food, highlighting its impact on the plasma concentration of the drug and its acid metabolite, informing pediatric dosing guidelines (Chan et al., 1983).
- Hyperkinetic disorders treatment studies: Ritalinic acid hydrochloride supports pharmacokinetic studies in children with hyperkinetic disorders, aiding in understanding how methylphenidate behaves within the body to improve therapeutic strategies (Hungund et al., 1979).
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Concerta is a registered trademark of ALZA Corporation
Ritalin is a registered trademark of Novartis Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
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Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Target Organs
Eyes,Central nervous system
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point(F)
49.5 °F - closed cup
Flash Point(C)
9.7 °C - closed cup
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Marion Letzel et al.
Chemosphere, 81(11), 1416-1422 (2010-10-12)
To investigate the occurrence and fate of ritalinic acid - the main human metabolite of the psychostimulant drug methylphenidate - in the aquatic environment, a HPLC-electrospray-MS/MS method for the quantification of ritalinic acid in wastewater, surface water and bank filtrate
A Solans et al.
Journal of chromatography. B, Biomedical applications, 658(2), 380-384 (1994-08-19)
Two analytical methods for the simultaneous detection in urine of methylphenidate and its main metabolite, ritalinic acid, are described. Both procedures are based on solid-phase extraction of urine samples on Bond Elut Certify columns, and capillary gas chromatographic-mass spectrometric detection
Emilia Marchei et al.
Therapeutic drug monitoring, 32(4), 508-511 (2010-06-11)
The pharmacokinetics of methylphenidate (MPH), a prescription amphetamine derivative used in the treatment of attention-deficit hyperactivity disorder, has been amply described in conventional biological matrices. Recently, the excretion of MPH and its principal metabolite, ritalinic acid (RA) in oral fluid
D R Doerge et al.
Rapid communications in mass spectrometry : RCM, 14(8), 619-623 (2000-04-29)
Methylphenidate (MP, Ritalin) is a psychotropic drug widely prescribed to children for treating the symptoms of attention deficit disorder with and without hyperactivity. Because little information exists about the effects of chronic MP administration on cognitive function in children, measures
Emilia Marchei et al.
Clinical chemistry, 56(4), 585-592 (2010-02-20)
We studied the excretion profile of methylphenidate (MPH) and its metabolite ritalinic acid (RA) in oral fluid and plasma, the oral fluid-to-plasma (OF/P) drug ratio, and the variations of oral fluid pH after drug administration. We analyzed oral fluid and
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