790981P
Avanti
14:0 PE-DTPA (Gd)
1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt), powder
Synonym(s):
1,2-ditetradecanoyl-sn-glycero-3-phosphoethanolamine- N-diethylenetriaminepentaacetic acid (gadolinium salt); DMPE-DTPA (Gd)
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All Photos(2)
About This Item
Empirical Formula (Hill Notation):
C47H90GdN6O17P
CAS Number:
Molecular Weight:
1199.47
UNSPSC Code:
12352211
NACRES:
NA.25
Recommended Products
Assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (790981P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 790981P
lipid type
phospholipids
shipped in
dry ice
storage temp.
−20°C
General description
14:0 PE-DTPA (Gd) has been used as a paramagnetic lipid to probe the orientation of a membrane protein in respect to the phospholipid bilayer membrane.
Lipid nanoparticles containing DMPE-DTPA(Gd) provide high quality contrast enhanced vascular MRI at 97% reduced dose of Gd and do not rely on renal clearance. Structure as shown by Cormode, D.P. et al.
Packaging
5 mL Amber Glass Screw Cap Vial (790981P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
Certificates of Analysis (COA)
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Alessandra Barazza et al.
Bioconjugate chemistry, 24(6), 1039-1048 (2013-04-27)
We have previously reported enhancing the imaging of atherosclerotic plaques in mice using reconstituted high density lipoproteins (HDL) as nanocarriers for the MRI contrast agent gadolinium (Gd). This study focuses on the underlying mechanisms of Gd delivery to atherosclerotic plaques.
David P Cormode et al.
Nano letters, 8(11), 3715-3723 (2008-10-23)
High density lipoprotein (HDL) is an important natural nanoparticle that may be modified for biomedical imaging purposes. Here we developed a novel technique to create unique multimodality HDL mimicking nanoparticles by incorporation of gold, iron oxide, or quantum dot nanocrystals
Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR
Hagn F, et al.
Nature Protocols, 13(1), 79-79 (2018)
Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform.
Cormode DP, et al.
Nano Letters, 8, 3715-3723 (2008)
Tot Bui et al.
PloS one, 5(9) (2010-10-12)
Gadolinium (Gd), with its 7 unpaired electrons in 4f orbitals that provide a very large magnetic moment, is proven to be among the best agents for contrast enhanced MRI. Unfortunately, the most potent MR contrast agent based on Gd requires
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