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A77806

Sigma-Aldrich

4-Aminopyrazolo[3,4-d]pyrimidine

98%

Synonym(s):

1H-Pyrazolo[3,4-d]pyrimidine-4-ylamine, 4-Amino-1H-pyrazolo[3,4-d]pyrimidine

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About This Item

Empirical Formula (Hill Notation):
C5H5N5
CAS Number:
2380-63-4
Molecular Weight:
135.13
EC Number:
219-174-6
MDL number:
MFCD00005688
UNSPSC Code:
12352100
PubChem Substance ID:
24891277
NACRES:
NA.22

Assay

98%

form

powder

mp

>325 °C (lit.)

SMILES string

Nc1ncnc2[nH]ncc12

InChI

1S/C5H5N5/c6-4-3-1-9-10-5(3)8-2-7-4/h1-2H,(H3,6,7,8,9,10)

InChI key

LHCPRYRLDOSKHK-UHFFFAOYSA-N

Application

Decreases serum cholesterol markedly in rats.[1][2]

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301,H315,H319,H335

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCD9262
07024DT
S16577
S27391
05030EM

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B Rodrigues et al.
Canadian journal of physiology and pharmacology, 70(9), 1271-1279 (1992-09-01)
The objective of this investigation was to test the hypothesis that the diabetes-induced reduction in lipoprotein lipase activity in cardiac myocytes may be due to hypertriglyceridemia. Administration of 4-aminopyrazolopyrimidine (50 mg/kg) to control rats for 24 h reduced plasma triacylglycerol
T Minami et al.
International journal of pancreatology : official journal of the International Association of Pancreatology, 13(3), 169-174 (1993-06-01)
A single dose of 4-aminopyrazolo(3,4-d) pyrimidine (4APP), an adenine analog, was orally administered at various concentrations of groups of mice and after 24 h, the plasma-alpha-amylase activity and cholesterol levels had significantly decreased in a dose-dependent manner. There was no
J F Goodrum
Journal of neurochemistry, 60(4), 1564-1566 (1993-04-01)
Following a nerve crush, cholesterol from degenerating myelin is retained within the nerve and reutilized for new myelin synthesis during nerve regeneration, apparently via a lipoprotein-mediated process. Because at least some serum components have access to the endoneurium of injured
S Azhar et al.
Biochemistry, 23(20), 4533-4538 (1984-09-25)
These studies were done to examine the effect of gonadotropin on rat luteal 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase activity (the rate-limiting step in cholesterol biosynthesis) in ovaries of pregnant mare's serum gonadotropin (PMSG)-human chorionic gonadotropin (hCG) primed rats. Administration
S Wu-Pong et al.
The Journal of investigative dermatology, 102(5), 799-802 (1994-05-01)
Barrier perturbation stimulates epidermal cholesterol synthesis, which plays an important role in restoring barrier function. In the present study, we examined whether changes in serum cholesterol levels or nutrition regulate epidermal cholesterol synthesis in hairless mice. Serum cholesterol levels were
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