807788

palmitic-acid-9-hydroxy-stearic-acid

95%

• Synonym(s): 9-PAHSA
• Empirical Formula (Hill Notation): C₃₄H₆₆O₄
• Molecular Weight: 538.89
• UNSPSC Code: 12352106
• PubChem Substance ID: 329768748
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 95%
• form: solid
• mp: 33.5 °C
• storage temp.: 2-8°C
• SMILES string: CCCCCCCCCC(OC(CCCCCCCCCCCCCCC)=O)CCCCCCCC(O)=O
• InChI: 1S/C34H66O4/c1-3-5-7-9-11-12-13-14-15-16-18-23-27-31-34(37)38-32(28-24-20-17-10-8-6-4-2)29-25-21-19-22-26-30-33(35)36/h32H,3-31H2,1-2H3,(H,35,36)
• InChI key: MHQWHZLXDBVXML-UHFFFAOYSA-N

Description

General description

Palmitic-acid-9-hydroxy-stearic-acid (9-PAHSA) is an isomeric form of bioactive fatty acid ester of hydroxyl-fatty acid (FAHFA).

Application

9-PAHSA is composed of palmitic acid attached to stearic acid and is in the class of branched lipids referred to as fatty acid esters of hydroxy fatty acids (FAHFAs). 9-PAHSA was found at increased levels in serum and white adipose tissue of insulin-sensitive mice. Levels were found to be lower in white adipose tissue of insulin-resistant humans. Studies of oral administration of 9-PAHSA to obese, diabetic mice showed improved glucose tolerance. In characterizing the mechanism, it was found that 9-PAHSA stimulates insulin and GLP-1 secretion and also enhances glucose transport and the Glut4 transporter through activation of GPR-120. 9-PAHSA was also shown to have anti-inflammatory properties.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable