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639869

Sigma-Aldrich

4-Phenylpiperidine

97%

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About This Item

Empirical Formula (Hill Notation):
C11H15N
CAS Number:
Molecular Weight:
161.24
Beilstein:
124508
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Assay

97%

mp

61-65 °C (lit.)

SMILES string

C1CC(CCN1)c2ccccc2

InChI

1S/C11H15N/c1-2-4-10(5-3-1)11-6-8-12-9-7-11/h1-5,11-12H,6-9H2

InChI key

UTBULQCHEUWJNV-UHFFFAOYSA-N

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Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Clandestine drug synthesis.
W H Soine
Medicinal research reviews, 6(1), 41-74 (1986-01-01)
Diane K Luci et al.
Bioorganic & medicinal chemistry letters, 17(23), 6489-6492 (2007-10-16)
Various 4-phenylpiperidine-benzoxazin-3-ones were synthesized and biologically evaluated as urotensin-II (U-II) receptor antagonists. Compound 12i was identified from in vitro evaluation as a low nanomolar antagonist against both rat and human U-II receptors. This compound showed in vivo efficacy in reversing
A G Ishkov et al.
Voprosy meditsinskoi khimii, 38(2), 25-28 (1992-03-01)
A rate of utilization of 4-phenyl piperidine and its 12 derivatives by brain monoamine oxidase (MAO) was studied as compared with typical neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The enzyme was isolated from P2 synaptosomal fraction of brain corpus striatum of Sprague-Dawley rats.
Barbara Wenzel et al.
Bioorganic & medicinal chemistry letters, 22(6), 2163-2166 (2012-03-01)
This Letter describes the synthesis of two regioisomers of a new class of vesamicol analogs as possible ligands for imaging the vesicular acetylcholine transporter in future PET studies. The two pyrrolovesamicols (±)-6a and (±)-6b were synthesized by nucleophilic ring opening
R A Glennon et al.
Journal of medicinal chemistry, 34(12), 3360-3365 (1991-12-01)
sigma receptors may represent an exciting new approach for the development of novel psychotherapeutic agents. Unfortunately, many of the commonly used sigma ligands lack selectivity (e.g., many bind at phencyclidine or dopamine receptors) or suffer from other serious drawbacks. Recently

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