385344
4-Hydroxy-6-(trifluoromethyl)pyrimidine
99%
Synonym(s):
6-(Trifluoromethyl)-4-pyrimidinol
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About This Item
Empirical Formula (Hill Notation):
C5H3F3N2O
CAS Number:
Molecular Weight:
164.09
Beilstein:
145548
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Assay
99%
mp
169-171 °C (lit.)
functional group
fluoro
SMILES string
Oc1cc(ncn1)C(F)(F)F
InChI
1S/C5H3F3N2O/c6-5(7,8)3-1-4(11)10-2-9-3/h1-2H,(H,9,10,11)
InChI key
LVOYSBZJJWPUBD-UHFFFAOYSA-N
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General description
4-Hydroxy-6-(trifluoromethyl)pyrimidine, a pyrimidine derivative, is a heterocyclic building block.
Application
4-Hydroxy-6-(trifluoromethyl)pyrimidine (6-(Trifluoromethyl)-4-pyrimidinol) may be used in the synthesis of 10-[3-(6-trifluoromethyl-pyrimidin-4-yloxy)-propoxy]-(20S)-camptothecin.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Qingyong Li et al.
Bioorganic & medicinal chemistry, 14(21), 7175-7182 (2006-07-28)
In an attempt to improve the antitumor activity and decrease the cytotoxicity of camptothecin, 18 new 10-substituted camptothecin derivatives were prepared. The cytotoxicity in vitro on cancer cell lines and antitumor activity in vivo, and inhibitory properties of topoisomerase I
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