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H4014

Sigma-Aldrich

25-Hydroxycholecalciferol

≥98% (HPLC)

Synonym(s):

25-Hydroxyvitamin D3

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About This Item

Empirical Formula (Hill Notation):
C27H44O2
CAS Number:
19356-17-3
Molecular Weight:
400.64
EC Number:
242-990-9
MDL number:
MFCD00867077
UNSPSC Code:
12352205
PubChem Substance ID:
24895612
NACRES:
NA.79

Quality Level

200

Assay

≥98% (HPLC)

form

powder

technique(s)

HPLC: suitable

color

white to off-white

storage temp.

−20°C

SMILES string

C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)CCC3=C

InChI

1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1

InChI key

JWUBBDSIWDLEOM-DTOXIADCSA-N

Gene Information

human ... VDR(7421)

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Application


  • Immunoassay development 25-Hydroxycholecalciferol: An investigation into the safety and efficacy of 25-hydroxycholecalciferol produced with Saccharomyces cerevisiae for animal feed emphasized its potential application in developing immunoassays that monitor vitamin D levels in animals, providing a basis for similar applications in human diagnostics (EFSA Panel on Additives and Products, 2023).

Biochem/physiol Actions

Ergocalciferol (vitamin D2) and 25-Hydroxycholecalciferol (vitamin D3) are the two form of vitamin D which are activated in vivo by hydroxylation. Vitamin D2 and D3 may be used in a wide range of studies to assess their effects on function such as immune function and calcium homeostasis.

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Product No.
Description
Pricing

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301 + H311,H330,H372

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - STOT RE 1 Oral

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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1α,25-Dihydroxyvitamin D2 ≥97.0% (sum of vitamin and previtamin, HPLC)

Sigma-Aldrich

17944

1α,25-Dihydroxyvitamin D2

Julia Höbaus et al.
International journal of cancer, 133(6), 1380-1388 (2013-03-07)
In colorectal cancer (CRC) the vitamin D catabolizing enzyme 1,25-dihydroxyvitamin D 24-hydroxylase (CYP24A1) is overexpressed with a potentially significant, positive impact on the catabolism of 1,25-dihydroxyvitamin D3 (1,25-D3 ). However, the underlying mechanism of CYP24A1 overexpression is poorly understood. In
M Abboud et al.
Endocrinology, 154(9), 3022-3030 (2013-07-05)
Little is known about the mechanism for the prolonged residence time of 25-hydroxyvitamin D (25OHD) in blood. Several lines of evidence led us to propose that skeletal muscle could function as the site of an extravascular pool of 25OHD. In
Richard McKenzie et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 12(9), 1726-1737 (2013-06-29)
To clarify the relation between UV exposure and vitamin D status, 201 volunteers wore personal electronic UV dosimeters during daylight hours, to record their UV exposure over a 10 week period when ambient UV levels were significantly less than the
Bianca Weinstock-Guttman et al.
Journal of neurology, neurosurgery, and psychiatry, 84(11), 1186-1191 (2013-04-19)
To investigate the associations of serum lipid profile with disease progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event. High density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were obtained in pretreatment
Jerry Liu et al.
Food chemistry, 140(3), 432-435 (2013-04-23)
There is little information on the vitamin D content of Australian red meat or on the possible influence of latitude on this content. To determine the content of vitamin D3 and 25-hydroxy-vitamin D3 (25OHD3), lamb and beef were analysed from
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