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D6001

Sigma-Aldrich

Dextran sulfate sodium salt from Leuconostoc spp.

average mol wt >500,000 (dextran starting material), contains 0.5-2.0% phosphate buffer, pH 6-8

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About This Item

CAS Number:
9011-18-1
MDL number:
MFCD00081551
UNSPSC Code:
12352201
NACRES:
NA.21

biological source

bacterial (Leuconostoc mesenteroides)

Quality Level

200

form

powder

optical activity

[α]/D 90 to 105 °, c = 6% (w/v) in water

mol wt

average mol wt >500,000 (dextran starting material)

contains

0.5-2.0% phosphate buffer, pH 6-8

composition

Sulfur Content, 16.0-19.0%

color

white to off-white

useful pH range

6.0-8.0 (1% in water)

solubility

H2O: 100 mg/mL

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General description

Dextran sulfate is a negatively charged sulfated polysaccharide, which is produced by the esterification of dextran with chlorosulphonic acid. It has antiviral, anticoagulant and adjuvant properties. Dextran is used to treat hemorrhage, burns, surgery and trauma. It enhances blood flow and blocks erythrocyte aggregation. Dextran decreases the risk of thrombosis and postoperative pulmonary emboli. It acts as a ribonuclease inhibitor.

Application

Dextran sulfate sodium salt Leuconostoc spp has been used:
  • to delipidate fatty plasma(67)(70)
  • to induce inflammatory and carcinogenic response in the distal colon of rodents(68)
  • for the preparation of 3,4-ethylenedioxythiophene (EDOT)(69)

Other Notes

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM0047
BCCK2169
BCCJ9030
BCCK0404
BCCH7065

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Seda Onder et al.
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Zora Djuric et al.
The Journal of nutritional biochemistry, 46, 90-99 (2017-05-10)
Dietary fish oils have potential for prevention of colon cancer, and yet the mechanisms of action in normal and tumor colon tissues are not well defined. Here we evaluated the impact of the colonic fatty acid milieu on the formation
The Molecular Biology of Poliovirus (2012)
Rheology of Industrial Polysaccharides: Theory and Applications (2012)
Julien Charest et al.
Developmental cell, 55(4), 483-499 (2020-10-02)
Combinatorial action of transcription factors (TFs) with partially overlapping expression is a widespread strategy to generate novel gene-expression patterns and, thus, cellular diversity. Known mechanisms underlying combinatorial activity require co-expression of TFs within the same cell. Here, we describe the
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Protocols

Dextran Sulfate

Dextran sulfates as sodium salts are water-soluble and stable, containing approximately 17% sulfur for various applications.

Dextran Sulfate

Dextran sulfates as sodium salts are water-soluble and stable, containing approximately 17% sulfur for various applications.

Dextran Sulfate

Dextran sulfates as sodium salts are water-soluble and stable, containing approximately 17% sulfur for various applications.

Dextran Sulfate

Dextran sulfates as sodium salts are water-soluble and stable, containing approximately 17% sulfur for various applications.

Related Content

Dextran and Polysaccharides Overview

Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, featuring a linear backbone of α-linked d-glucopyranosyl repeating units.

Dextran and Polysaccharides Overview

Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, featuring a linear backbone of α-linked d-glucopyranosyl repeating units.

Dextran and Polysaccharides Overview

Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, featuring a linear backbone of α-linked d-glucopyranosyl repeating units.

Dextran and Polysaccharides Overview

Dextrans are polysaccharides with molecular weights ≥1,000 Dalton, featuring a linear backbone of α-linked d-glucopyranosyl repeating units.

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