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  • A newly synthesized compound, 4'-geranyloxyferulic acid-N(omega)-nitro-L-arginine methyl ester suppresses inflammation-associated colorectal carcinogenesis in male mice.

A newly synthesized compound, 4'-geranyloxyferulic acid-N(omega)-nitro-L-arginine methyl ester suppresses inflammation-associated colorectal carcinogenesis in male mice.

International journal of cancer (2014-01-30)
Masahito Shimizu, Takahiro Kochi, Yohei Shirakami, Salvatore Genovese, Francesco Epifano, Serena Fiorito, Takayuki Mori, Takuji Tanaka, Hisataka Moriwaki
要旨

We previously reported the cancer chemopreventive activity of 4'-geranyloxyferulic acid (GOFA, Miyamoto et al., Nutr Cancer 2008; 60:675-84) and a β-cyclodextrin inclusion compound of GOFA (Tanaka et al., Int J Cancer 2010; 126:830-40) in colitis-related colorectal carcinogenesis. In our study, the chemopreventive effects of a newly synthesized GOFA-containing compound, GOFA-N(omega)-nitro-L-arginine methyl ester (L-NAME), which inhibits inducible nitric oxide (iNOS) and cyclooxygenase-2 (COX) enzymes, were investigated using a colitis-associated mouse colorectal carcinogenesis model with azoxymethane (AOM) and dextran sodium sulfate (DSS). The dietary administration of GOFA-L-NAME after the AOM and DSS treatments significantly reduced the multiplicity of adenocarcinomas (inhibition rates: 100 ppm, 84%, p < 0.001; 500 ppm, 94%, p < 0.001) compared with the AOM + DSS group. Dietary GOFA-L-NAME significantly decreased the proliferation (p < 0.001) and increased the apoptosis (p < 0.001) of colonic adenocarcinoma cells. A subsequent short-term experiment revealed that dietary GOFA-L-NAME decreased the mRNA expression of inflammatory enzymes, such as iNOS and COX-2, and proinflammatory cytokines, such as tumor necrosis factor-α, interleukin (IL)-1β, IL-6 and macrophage inflammatory protein (MIP)-2 in the colonic mucosa of mice that received 1.5% DSS in their drinking water for 7 days. Our findings indicate that GOFA-L-NAME is able to inhibit colitis-associated colon carcinogenesis by modulating inflammation, proliferation, apoptosis and the expression of proinflammatory cytokines in mice.

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Sigma-Aldrich
Nω-ニトロ-L-アルギニンメチルエステル 塩酸塩, ≥97% (TLC), powder
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カタログ番号容量在庫状況単価数量
250 mg
販売中
詳細...
MXP 681.00
1 g
出荷予定日 2025年3月22日
MXP 1,411.00
5 g
出荷予定日 2025年3月22日
MXP 3,703.00
10 g
販売中
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MXP 5,416.00
25 g
販売中
詳細...
MXP 12,845.00
Sigma-Aldrich
Nω-ニトロ-L-アルギニン, ≥98% (TLC)
ログイン組織・契約価格を表示する
カタログ番号容量在庫状況単価数量
250 mg
販売中
詳細...
MXP 681.00
1 g
出荷予定日 2025年3月22日
MXP 1,411.00
5 g
出荷予定日 2025年3月22日
MXP 3,703.00
10 g
販売中
詳細...
MXP 5,416.00
25 g
販売中
詳細...
MXP 12,845.00