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The role of iron and reactive oxygen species in cell death.

The role of iron and reactive oxygen species in cell death.

Nature chemical biology (2013-12-19)

Scott J Dixon, Brent R Stockwell

要旨

The transition metal iron is essential for life, yet potentially toxic iron-catalyzed reactive oxygen species (ROS) are unavoidable in an oxygen-rich environment. Iron and ROS are increasingly recognized as important initiators and mediators of cell death in a variety of organisms and pathological situations. Here, we review recent discoveries regarding the mechanism by which iron and ROS participate in cell death. We describe the different roles of iron in triggering cell death, targets of iron-dependent ROS that mediate cell death and a new form of iron-dependent cell death termed ferroptosis. Recent advances in understanding the role of iron and ROS in cell death offer unexpected surprises and suggest new therapeutic avenues to treat cancer, organ damage and degenerative disease.

材料

製品番号

ブランド

製品内容

Sigma-Aldrich

Carbonyl iron, ≥97% Fe basis

Sigma-Aldrich

鉄, puriss. p.a., carbonyl-Iron powder, low in magnesium and manganese compounds, ≥99.5% (RT)

Sigma-Aldrich

鉄, granular, 10-40 mesh, >99.99% trace metals basis

Sigma-Aldrich

鉄, foil, thickness 0.1 mm, ≥99.9% trace metals basis

Sigma-Aldrich

鉄, chips, 99.98% trace metals basis

Sigma-Aldrich

鉄, wire, diam. 1.0 mm, ≥99.9% trace metals basis

鉄, foil, 100x100mm, thickness 0.25mm, hard, 99.5%

Sigma-Aldrich

鉄, foil, thickness 0.25 mm, ≥99.99% trace metals basis

鉄, foil, 300x300mm, thickness 0.1mm, hard, 99.5%

鉄, tube, 200mm, outside diameter 8.0mm, inside diameter 5mm, wall thickness 1.5mm, annealed, 99.5%

鉄, rod, 200mm, diameter 25mm, as drawn, 98+%

鉄, foil, 100x100mm, thickness 0.125mm, as rolled, 99.99+%

鉄, foil, 100x100mm, thickness 1.0mm, as rolled, 99.5%

鉄, rod, 100mm, diameter 100mm, as drawn, armcO« soft ingot 99.8%

鉄, foil, 150x150mm, thickness 1.5mm, as rolled, 99.5%

鉄, rod, 50mm, diameter 5.0mm, as drawn, 99.99+%

鉄, rod, 100mm, diameter 2.0mm, as drawn, 99.95%

鉄, foil, 25x25mm, thickness 0.9mm, as rolled, 99.5%

鉄, rod, 150mm, diameter 6.0mm, as drawn, 99.99+%

鉄, rod, 500mm, diameter 4.8mm, as drawn, 98+%

鉄, foil, 100x100mm, thickness 0.5mm, hard, 99.5%

鉄, tube, 200mm, outside diameter 5.0mm, inside diameter 4.5mm, wall thickness 0.25mm, as drawn, 99.5%

鉄, foil, 25x25mm, thickness 1.0mm, as rolled, 99.5%

鉄, rod, 200mm, diameter 9.5mm, as drawn, soft ingot 99.8+%

鉄, foil, 50x50mm, thickness 0.1mm, hard, 99.5%

鉄, foil, 25x25mm, thickness 0.5mm, hard, 99.5%

鉄, rod, 1000mm, diameter 9.5mm, as drawn, 98+%

鉄, rod, 200mm, diameter 6.35mm, as drawn, soft ingot 99.8%

鉄, foil, 300x300mm, thickness 0.125mm, hard, 99.5%

鉄, foil, 50x50mm, thickness 0.20mm, hard, 99.5%