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Merck
  • Tracking injectable microspheres in dynamic tissues with encapsulated superparamagnetic iron oxide nanoparticles.

Tracking injectable microspheres in dynamic tissues with encapsulated superparamagnetic iron oxide nanoparticles.

Macromolecular bioscience (2012-11-06)
Travelle Franklin-Ford, Nehal Shah, Ellen Leiferman, Connie S Chamberlain, Amish Raval, Ray Vanderby, William L Murphy
PMID23124987
要旨

Trackable spheres of similar size to those typically used for sustained protein delivery are prepared by incorporating superparamagnetic iron oxide (SPIO) nanoparticles into the core of poly(lactide-co-glycolide) microspheres. The visibility of injections in static and temporally in dynamic tissue systems is demonstrated. This method improves upon other, less sensitive imaging modalities in their ability to track injectable delivery systems. The results obtained confirm the localization of microspheres to the injected target area and highlight the novelty of tracking delivery vehicles for other applications.

材料
製品番号
ブランド
製品内容
719897
Sigma-Aldrich
Resomer® RG 502H、ポリ(D,L-ラクチド-コ-グリコリド), acid terminated, viscosity 0.16-0.24 dL/g 
P2191
Sigma-Aldrich
ポリ(D,L-ラクチド-コ-グリコリド), lactide:glycolide (50:50), mol wt 30,000-60,000
P1941
Sigma-Aldrich
ポリ(D,L-ラクチド-コ-グリコリド), lactide:glycolide (75:25), mol wt 66,000-107,000
719900
Sigma-Aldrich
Resomer® RG 504 H、ポリ(D,L-ラクチド-co-グリコリド), acid terminated, lactide:glycolide 50:50, Mw 38,000-54,000
719870
Sigma-Aldrich
Resomer® RG 503 H、ポリ(D,L-ラクチド-co-グリコリド), acid terminated, lactide:glycolide 50:50, Mw 24,000-38,000
719919
Sigma-Aldrich
Resomer® RG 752 H、ポリ(D,L-ラクチド-co-グリコリド), acid terminated, lactide:glycolide 75:25, Mw 4,000-15,000
719889
Sigma-Aldrich
Resomer® RG 502、ポリ(D,L-ラクチド-co-グリコリド), lactide:glycolide 50:50, ester terminated, Mw 7,000-17,000
P2066
Sigma-Aldrich
ポリ(D,L-ラクチド-コ-グリコリド), lactide:glycolide 65:35, Mw 40,000-75,000
430471
Sigma-Aldrich
ポリ(D,L-ラクチド-コ-グリコリド), ester terminated, Mw 50,000-75,000
739944
Sigma-Aldrich
Resomer® RG 504, Poly(D,L-lactide-co-glycolide), lactide:glycolide 50:50, ester terminated, Mw 38,000-54,000
739960
Sigma-Aldrich
Resomer® RG 505、ポリ(D,L-ラクチド-co-グリコリド), ester terminated, Mw 54,000-69,000
719927
Sigma-Aldrich
Resomer® RG 756 S, ポリ(D,L-ラクチド-co-グリコリド), ester terminated, lactide:glycolide 75:25, Mw 76,000-115,000
739952
Sigma-Aldrich
Resomer® RG 503、ポリ(D,L-ラクチド-co-グリコライド), lactide:glycolide 50:50, ester terminated, Mw 24,000-38,000
719862
Sigma-Aldrich
Resomer® RG 653 H、ポリ(D,L-ラクチド-co-グリコリド), acid terminated, Mw 24,000-38,000
739979
Sigma-Aldrich
Resomer® RG 858 S, ポリ(D,L-ラクチド-co-グリコリド), ester terminated, lactide:glycolide 85:15, Mw 190,000-240,000