コンテンツへスキップ
Merck
  • High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation.

High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation.

Nature communications (2020-04-09)
Wei He, Jinzhi Xu, Ruoyu Mu, Qiu Li, Da-Lun Lv, Zhen Huang, Junfeng Zhang, Chunming Wang, Lei Dong
要旨

High-salt diets are associated with an elevated risk of autoimmune diseases, and immune dysregulation plays a key role in cancer development. However, the correlation between high-salt diets (HSD) and cancer development remains unclear. Here, we report that HSD increases the local concentration of sodium chloride in tumour tissue, inducing high osmotic stress that decreases both the production of cytokines required for myeloid-derived suppressor cells (MDSCs) expansion and MDSCs accumulation in the blood, spleen, and tumour. Consequently, the two major types of MDSCs change their phenotypes: monocytic-MDSCs differentiate into antitumour macrophages, and granulocytic-MDSCs adopt pro-inflammatory functions, thereby reactivating the antitumour actions of T cells. In addition, the expression of p38 mitogen-activated protein kinase-dependent nuclear factor of activated T cells 5 is enhanced in HSD-induced M-MDSC differentiation. Collectively, our study indicates that high-salt intake inhibits tumour growth in mice by activating antitumour immune surveillance through modulating the activities of MDSCs.

材料
製品番号
ブランド
製品内容

Sigma-Aldrich
MISSION® esiRNA, targeting human MAPK14
ログイン組織・契約価格を表示する
カタログ番号容量在庫状況単価数量
20 μg
1 出荷予定日 2025年2月25日
¥38,100
50 μg
1 出荷予定日 2025年2月25日
¥68,300
Sigma-Aldrich
MISSION® esiRNA, targeting human NFAT5
ログイン組織・契約価格を表示する
カタログ番号容量在庫状況単価数量
20 μg
1 出荷予定日 2025年2月25日
¥38,100
50 μg
1 出荷予定日 2025年2月25日
¥68,300