UC148
6-ヒドロキシクロルゾキサゾン
≥98% (HPLC), solid, chlorzoxazone metabolite
別名:
5-クロロ-6-ヒドロキシ-2(3H)-ベンゾキサゾロン, 5-クロロ-6-ヒドロキシベンゾキサゾン
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この商品について
実験式（ヒル表記法）:
C7H4ClNO3
CAS番号:
分子量:
185.56
UNSPSC Code:
12161501
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
製品名
6-ヒドロキシクロルゾキサゾン, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
solid
color
white to pink
solubility
methanol: soluble
storage temp.
2-8°C
SMILES string
Oc1cc2OC(=O)Nc2cc1Cl
InChI
1S/C7H4ClNO3/c8-3-1-4-6(2-5(3)10)12-7(11)9-4/h1-2,10H,(H,9,11)
InChI key
AGLXDWOTVQZHIQ-UHFFFAOYSA-N
Application
CYP2E1および1A2によるクロルゾキサゾンの代謝産物です。
6-Hydroxychlorzoxazone has been used for HPLC-based metabolic assays of chlorzoxazone[1].
6-hydroxy Chlorzoxazone has been used: as a reference standard to monitor substrate depletion or 6-hydroxy chlorzoxazone formation by cytochrome P450 family 2 subfamily E member 1 (CYP2E1)in recombinant human enzyme screening. 6-Hydroxychlorzoxazone has been used for high-performance liquid chromatography (HPLC)-based metabolic assays of chlorzoxazone.[1]
Biochem/physiol Actions
6-hydroxy Chlorzoxazone is a novel metabolite of chlorzoxazone.[2] It is formed by the hydroxylation of chlorzoxazone by cytochrome P450 family 2 subfamily E member 1 (CYP2E1) enzyme. The determination of formation and clearance of 6-hydroxychlorzoxazone is used as a reliable marker of CYP2E1 metabolic activity.[2]
Packaging
底の開いたガラス瓶内容物は内部に挿入され接着された円錐部に入っています。
Preparation Note
6-Hydroxychlorzoxazone is soluble in methanol.
1 of 1
当該品目 | |||
|---|---|---|---|
| form solid | form powder | form powder | form solid |
| assay ≥98% (HPLC) | assay ≥98% (TLC) | assay ≥98% (HPLC) | assay ≥98% |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. room temp | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility methanol: soluble | solubility DMSO: 50 mg/mL, clear | solubility DMSO: 25 mg/mL, clear | solubility DMSO: >20 mg/mL, H2O: insoluble |
| color white to pink | color white to off-white | color white to beige | color white to off-white |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves