T9533

トランスフォーミング増殖因子-α ラット由来

powder, synthetic, γ-irradiated, suitable for cell culture

• 別名: TGF-α
• 実験式（ヒル表記法）: C₂₄₄H₃₆₇N₇₁O₇₁S₆
• CAS番号: 89899-53-6
• 分子量: 5623.35
• MDL番号: MFCD00082077
• UNSPSCコード: 12352200

特性

• 由来生物: synthetic
• 無菌性: γ-irradiated
• アッセイ: ~90% (HPLC)
• 形状: powder
• 有効性: 0.02-2.0 ng/mL EC₅₀ (using Balb/MK 1)
• 分子量: 5.5 kDa
• 組成: Peptide content, ~80%
• 保管条件: avoid repeated freeze/thaw cycles
• テクニック: cell culture | mammalian: suitable
• 不純物: endotoxin, tested
• UniProtアクセッション番号: P01134
• 保管温度: −20°C
• 遺伝子情報: rat ... Tgfa(24827) , Tgfa(24827)

詳細

Amino Acid Sequence

Val-Val-Ser-His-Phe-Asn-Lys-Cys-Pro-Asp-Ser-His-Thr-Gln-Tyr-Cys-Phe-His-Gly-Thr-Cys-Arg-Phe-Leu-Val-Gln-Glu-Glu-Lys-Pro-Ala-Cys-Val-Cys-His-Ser-Gly-Tyr-Val-Gly-Val-Arg-Cys-Glu-His-Ala-Asp-Leu-Leu-Ala [Disulfide Bridges: 8-21; 16-32; 34-43]

生物化学的／生理学的作用

Transforming growth factor-α (TGF-α), is a 5.5 kDa polypeptide containing 50 amino acids in its mature form. It was originally identified as an agent that reversibly confers a transformed phenotype upon normal non-neoplastic cells, such as normal rat kidney fibroblasts. This activity requires the presence of transforming growth factor-β (TGF-β), which potentiates the action of TGF-α via a separate receptor. TGF-α is synthesized by monocytes, keratinocytes and many tissues and tumors. Mice genetically engineered to be lacking TGF-α expression showed no abnormalities except for the detection of a "wavy" hair coat. TGF-α exerts its action through the EGF receptor.

安全性情報

• 保管分類コード: 13 - Non Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)