SRP6577

TAF1 (1371-1496) GST tag human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

• 別名: BA2R, CCG1, CCGS, DYT3, KAT4, NSCL2, TAF1 RNA Polymerase II, TAF2A, TAFII250, TATA Box Binding Protein (TBP)-Associated Factor, XDP
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• 由来生物: human
• リコンビナント: expressed in E. coli
• アッセイ: ≥95% (SDS-PAGE)
• 形状: liquid
• 分子量: 41.7 kDa (1371-1496 aa + NT GST Tag)
• 包装: pkg of 100 μg; pkg of 20 μg
• UniProtアクセッション番号: P21675
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... TAF1(6872)

詳細

詳細

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. TAF1 is a component of transcription factor IID, and binds to core promoter sequences at the transcription start site. TAF1 helps control transcription by both its kinase and histone acetyltransferase enzymatic activities. It interacts with transcriptional activators such as the androgen receptor to promote transcription. Disruption of TAF1 causes dystonia 3 (X-linked torsion dystonia) and decreased apoptosis. This protein product contains the first bromodomain of TAF1.

物理的形状

50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H317,H319
• 注意書き: P261 - P264 - P272 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Sens. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable