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由来生物
human
リコンビナント
expressed in HEK 293 cells
タグ
6-His tagged (C-terminus)
アッセイ
≥92% (SDS-PAGE)
形状
lyophilized
分子量
calculated mol wt 31 kDa
observed mol wt 33 kDa by SDS-PAGE (reducing) (Ala 19 is the predicted N-terminal .)
包装
pkg of 10 μg
不純物
<1 EU/μg endotoxin (LAL test)
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
human ... CA4(762)
詳細
Carbonic anhydrase 4 (CA4) is a 35kDa protein, encoded by the gene mapped to human chromosome 17q23.1-23.2. It is expressed on extracellular surfaces of certain endothelial and epithelial cells. CA4 is one among the 12 isozymes of carbonic anhydrase.
Carbonic anhydrase 4 (CA4) is also known as Carbonate dehydratase IV, Carbonic anhydrase IV, which belongs to the α-carbonic anhydrase family. CA4 may stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid. The enzyme regulation is activated by histamine, L-adrenaline, D-phenylalanine, L- and D-histidine. CA4 can interact with SLC4A4.
生物化学的／生理学的作用
Carbonic anhydrase 4 (CA4) plays a vital role in CO2 hydration activity. It also catalyzes the dehydration of HCO3. In addition, it also facilitates CO2 and HCO3 transport in various vital tissues like kidney and lung Polymorphism in the gene has been associated with the development of sporadic retinitis pigmentosa (RP).
物理的形状
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH 7.5. Normally Mannitol or Trehalose is added as protectants before lyophilization.
再構成
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SRP6489-BULK:
SRP6489-10UG:
SRP6489-VAR:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Familial microduplication of 17q23.1?q23.2 involving TBX4 is associated with congenital clubfoot and reduced penetrance in females.
Peterson J F, et al.
American Journal of Medical Genetics. Part A, 164(2), 364-369 (2014)
Li-Li Huang et al.
Journal of clinical and translational hepatology, 11(3), 605-613 (2023-03-28)
Hepatocellular carcinoma (HCC) is one of the most common types of cancer, often resulting in death. Augmenter of liver regeneration (ALR), a widely expressed multifunctional protein, has roles in liver disease. In our previous study, we reported that ALR knockdown
Screening for the Carbonic Anhydrase IV Gene Mutations in Chinese Retinitis Pigmentosa Patients
Tian Y, et al.
Current Eye Research, 35(5), 440-444 (2010)
Membrane associated carbonic anhydrase IV (CA IV): a personal and historical perspective.
Waheed A, et al.
Sub-Cellular Biochemistry, 157-179 (2014)
Rupak Datta et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(9), 3437-3442 (2009-02-13)
Missense mutations in the carbonic anhydrase IV (CA IV) gene have been identified in patients with an autosomal dominant form of retinitis pigmentosa (RP17). We used two transient expression systems to investigate the molecular mechanism by which the newly identified
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