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由来生物
human
リコンビナント
expressed in HEK 293 cells
タグ
6-His tagged (C-terminus)
無菌性
sterile
アッセイ
≥90% (SDS-PAGE)
形状
lyophilized
分子量
calculated mol wt 67 kDa
observed mol wt 67 kDa (DTT-reduced. Protein migrates due to glycosylation. Gln 23 is the predicted N-terminal.)
包装
pkg of 25 μg
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
human ... CDH1(999)
詳細
Cadherin-1 (CDH1) is a transmembrane protein, which is mainly involved in cell adhesion in normal epithelia. The associated gene is mapped to human chromosome 16q22.1.
生物化学的/生理学的作用
Cadherin-1 (CDH1) stabilizes the cell adhesion in normal cells and also helps in signaling via association with β catenin. Mutations in the CDH1 gene are linked with oral clefts in the Thai population. CDH1 works as a tumor suppressor in various cancers. Low expression of CDH1 increases cellular invasive and metastatic potential. For instance, low expression of this gene is associated with poor survival of patients with esophageal cancer.
物理的形状
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
再構成
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SRP6426-25UG:
試験成績書(COA)
製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Assignment1 of the E-cadherin gene (CDH1) to chromosome 16q22.1 by radiation hybrid mapping.
Cytogenetics and Cell Genetics, 83, 82-82 (1998)
Decreased expression of CDH1 or CTNNB1 affects poor prognosis of patients with esophageal cancer.
World Journal of Surgical Oncology, 14, 240-240 (2016)
miR-92a-3p Exerts Various Effects in Glioma and Glioma Stem-Like Cells Specifically Targeting CDH1/?-Catenin and Notch-1/Akt Signaling Pathways.
International Journal of Molecular Sciences, 17, E1799-E1799 (2016)
Variants of the CDH1 (E-Cadherin) Gene Associated with Oral Clefts in the Thai Population.
Genetic Testing and Molecular Biomarkers, 20, 406-406 (2016)
PloS one, 17(9), e0274919-e0274919 (2022-09-23)
Aim to investigate the effect of miR-206 on the growth and metastasis of breast cancer stem cells and clarify the precise mechanism of miR-206 on EVI-1-mediated CALR expression in driving malignant phenotype. Our results showed that miR-206 mimics suppressed CALR
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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